Nitration of 2 '-deoxyguanosine by a NO/O-2 gas mixture: Identification and characterization of N-2-nitro-2 '-deoxyguanosine

[GRAPHICS] A gas mixture of NO and O-2 was bubbled into 2'-deoxyguanosine solution at neutral pH and 37 degreesC. A novel nitrated nucleoside was generated in the reaction mixture in addition to 8-nitroguanine, 8-nitroxanthine, 2'-deoxyxanthosine, xanthine, and guanine. The novel nucleosid...

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Bibliographic Details
Published inOrganic letters Vol. 5; no. 18; pp. 3173 - 3176
Main Authors Yamada, M, Suzuki, T, Kanaori, K, Tajima, K, Sakamoto, S, Kodaki, T, Makino, K
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 04.09.2003
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
OXIDATION
INDUCED DEAMINATION
CELLS
IN-VITRO
DNA
NUCLEOSIDES
NITRIC-OXIDE
GUANINE
AQUEOUS-SOLUTION
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Summary:[GRAPHICS] A gas mixture of NO and O-2 was bubbled into 2'-deoxyguanosine solution at neutral pH and 37 degreesC. A novel nitrated nucleoside was generated in the reaction mixture in addition to 8-nitroguanine, 8-nitroxanthine, 2'-deoxyxanthosine, xanthine, and guanine. The novel nucleoside was identified as N(2-)nitro-2'-deoxyguanosine by spectrometric data.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0300468