Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis

The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-di...

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Bibliographic Details
Published inNutraceuticals Vol. 4; no. 2; pp. 273 - 282
Main Authors Ravnikar, Matjaž, Štrukelj, Borut, Otašević, Biljana, Sirše, Mateja
Format Journal Article
LanguageEnglish
Published MDPI AG 21.05.2024
Subjects
anti-diabetics
diabetes
fomentariol
Fomes fomentarius
fungi
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Summary:The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha-glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.
ISSN:1661-3821
1661-3821
DOI:10.3390/nutraceuticals4020017