Purity determination of natural toxin standards by NMR spectroscopy

  Accurate quantity of the diarrhetic shellfish poisoning Okadaic acid and Ciguatoxins which are the causative substance of ciguatera fish poisoning were determined by qNMR. The signals for use of determining quantity were carefully chosen because both substances are large polyether cyclic compounds...

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Bibliographic Details
Published inJSM Mycotoxins Vol. 69; no. 1; pp. 21 - 26
Main Author Kato, Tsuyoshi
Format Journal Article
LanguageEnglish
Japanese
Published Tokyo Japanese Society of Mycotoxicology 31.01.2019
Japan Science and Technology Agency
Subjects
AQARI
Ciguatera
Ciguatoxin
Cyclic compounds
Diarrhetic shellfish poisoning
Magnetic resonance spectroscopy
Molecular weight
NMR
NMR spectroscopy
Nuclear magnetic resonance
Okadaic acid
Poisoning
qNMR
Shellfish
Toxins
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ISSN0285-1466
1881-0128
DOI10.2520/myco.69-1-1

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Summary:  Accurate quantity of the diarrhetic shellfish poisoning Okadaic acid and Ciguatoxins which are the causative substance of ciguatera fish poisoning were determined by qNMR. The signals for use of determining quantity were carefully chosen because both substances are large polyether cyclic compounds. An internal standard material enable to be removable after measurement was used for quantification of the precious marine biotoxins. The uncertainty estimated for the quantitative values of both substances increased with decreasing sample amounts for measurement. Quantification of cyclic polyether compounds having molecular weight around 1000 was achievable for subjects at least 0.01 mg by employing qNMR .
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ISSN:0285-1466
1881-0128
DOI:10.2520/myco.69-1-1