Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease

Male urethral stricture disease is highly prevalent and difficult to treat due to potential complications. Minimally invasive treatments tend to have high recurrence rates, keeping urethroplasty as the gold standard. Collagenase Clostridium histolyticum (CCH) has been used in humans to treat fibrosi...

Full description

Saved in:
Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 15; no. 9
Main Authors Wiegand, Lucas R, Tran, Thanh Q, Heinsimer, Kevin, Shah, Bhavik
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 11.09.2023
Cureus
Subjects
Catheters
Collagen
Fistula
Hematuria
Patients
Quality of life
Ultrasonic imaging
Urology
Online AccessGet full text

Cover

More Information
Summary:Male urethral stricture disease is highly prevalent and difficult to treat due to potential complications. Minimally invasive treatments tend to have high recurrence rates, keeping urethroplasty as the gold standard. Collagenase Clostridium histolyticum (CCH) has been used in humans to treat fibrosis in a minimally invasive manner. Herein, we present the preliminary results from treatments of three males with urethral stricture as a feasibility and safety evaluation of the first-in-human CCH treatment for male urethral stricture disease.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.45051