Atrioventricular Node Dysfunction in Heart Failure: New Horizons from Pathophysiology to Therapeutic Perspectives

Heart failure (HF) is characterized by adverse myocardial remodeling involving both the contractile cardiomyocytes and the conduction tissue. HF is often associated with atrioventricular (AV) node dysfunction, which frequently leads to conduction delays and subsequent dyssynchrony ultimately related...

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Published inJournal of cardiovascular development and disease Vol. 12; no. 8; p. 310
Main Authors Fumarulo, Isabella, Salerno, Elia Nunzio Maria, De Prisco, Andrea, Ravenna, Salvatore Emanuele, Grimaldi, Maria Chiara, Burzotta, Francesco, Aspromonte, Nadia
Format Journal Article Book Review
LanguageEnglish
Published Basel MDPI AG 15.08.2025
MDPI
Subjects
Cardiomyocytes
Coronary vessels
Heart failure
Ischemia
Metabolism
Mortality
Pacemakers
Pathophysiology
Review
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Abstract Heart failure (HF) is characterized by adverse myocardial remodeling involving both the contractile cardiomyocytes and the conduction tissue. HF is often associated with atrioventricular (AV) node dysfunction, which frequently leads to conduction delays and subsequent dyssynchrony ultimately related to adverse clinical outcomes. Despite its clinical relevance, AV node pathology in HF remains poorly explored. This review aims to investigate the pathophysiology underlying AV node dysfunction and the clinical implications for patients with HF, and to provide an overview of current therapeutic approaches, including an analysis of potential future treatments.
AbstractList Heart failure (HF) is characterized by adverse myocardial remodeling involving both the contractile cardiomyocytes and the conduction tissue. HF is often associated with atrioventricular (AV) node dysfunction, which frequently leads to conduction delays and subsequent dyssynchrony ultimately related to adverse clinical outcomes. Despite its clinical relevance, AV node pathology in HF remains poorly explored. This review aims to investigate the pathophysiology underlying AV node dysfunction and the clinical implications for patients with HF, and to provide an overview of current therapeutic approaches, including an analysis of potential future treatments.
Author De Prisco, Andrea
Burzotta, Francesco
Fumarulo, Isabella
Salerno, Elia Nunzio Maria
Grimaldi, Maria Chiara
Aspromonte, Nadia
Ravenna, Salvatore Emanuele
AuthorAffiliation 3 Department of Life Science, Health and Health Professions, Università degli Studi Link, 00165 Rome, Italy
2 Department of Cardiovascular Sciences, Catholic University of the Sacred Heart, 00168 Rome, Italy
1 Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy; isabella.fumarulo@guest.policlinicogemelli.it (I.F.); elianunziomaria.salerno01@icatt.it (E.N.M.S.)
AuthorAffiliation_xml – name: 2 Department of Cardiovascular Sciences, Catholic University of the Sacred Heart, 00168 Rome, Italy
– name: 1 Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy; isabella.fumarulo@guest.policlinicogemelli.it (I.F.); elianunziomaria.salerno01@icatt.it (E.N.M.S.)
– name: 3 Department of Life Science, Health and Health Professions, Università degli Studi Link, 00165 Rome, Italy
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Snippet Heart failure (HF) is characterized by adverse myocardial remodeling involving both the contractile cardiomyocytes and the conduction tissue. HF is often...
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Aggregation Database
Index Database
StartPage 310
SubjectTerms Cardiomyocytes
Coronary vessels
Heart failure
Ischemia
Metabolism
Mortality
Pacemakers
Pathophysiology
Review
Title Atrioventricular Node Dysfunction in Heart Failure: New Horizons from Pathophysiology to Therapeutic Perspectives
URI https://www.proquest.com/docview/3244041398
https://pubmed.ncbi.nlm.nih.gov/PMC12386772
Volume 12
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