Atrioventricular Node Dysfunction in Heart Failure: New Horizons from Pathophysiology to Therapeutic Perspectives

Heart failure (HF) is characterized by adverse myocardial remodeling involving both the contractile cardiomyocytes and the conduction tissue. HF is often associated with atrioventricular (AV) node dysfunction, which frequently leads to conduction delays and subsequent dyssynchrony ultimately related...

Full description

Saved in:
Bibliographic Details
Published inJournal of cardiovascular development and disease Vol. 12; no. 8; p. 310
Main Authors Fumarulo, Isabella, Salerno, Elia Nunzio Maria, De Prisco, Andrea, Ravenna, Salvatore Emanuele, Grimaldi, Maria Chiara, Burzotta, Francesco, Aspromonte, Nadia
Format Journal Article Book Review
LanguageEnglish
Published Basel MDPI AG 15.08.2025
MDPI
Subjects
Cardiomyocytes
Coronary vessels
Heart failure
Ischemia
Metabolism
Mortality
Pacemakers
Pathophysiology
Review
Online AccessGet full text

Cover

More Information
Summary:Heart failure (HF) is characterized by adverse myocardial remodeling involving both the contractile cardiomyocytes and the conduction tissue. HF is often associated with atrioventricular (AV) node dysfunction, which frequently leads to conduction delays and subsequent dyssynchrony ultimately related to adverse clinical outcomes. Despite its clinical relevance, AV node pathology in HF remains poorly explored. This review aims to investigate the pathophysiology underlying AV node dysfunction and the clinical implications for patients with HF, and to provide an overview of current therapeutic approaches, including an analysis of potential future treatments.
Bibliography:content type line 1
SourceType-Scholarly Journals-1
ObjectType-Review-1
ISSN:2308-3425
2308-3425
DOI:10.3390/jcdd12080310