A CASE OF Tn-POLYAGGLUTINATION WITH PANCYTOPENIA
Polyagglutination of erythrocytes is observed when most normal ABO-compatible human serum agglutinate the tested red cells. Recently we had a case of polyagglutination caused by the Tn antigen. Tn-polyagglutination was detected in the blood of a 78-years-old female patient with pancytopenia. The tru...
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| Published in | Journal of the Japan Society of Blood Transfusion Vol. 30; no. 3; pp. 192 - 198 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Transfusion Medicine and Cell Therapy
1984
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| Online Access | Get full text |
| ISSN | 0546-1448 1883-8383 |
| DOI | 10.3925/jjtc1958.30.192 |
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| Abstract | Polyagglutination of erythrocytes is observed when most normal ABO-compatible human serum agglutinate the tested red cells. Recently we had a case of polyagglutination caused by the Tn antigen. Tn-polyagglutination was detected in the blood of a 78-years-old female patient with pancytopenia. The true blood group of the patient was O, but her cells had an aquired A-like specificity. Confirmation that the polyagglutination was caused by Tn activation was established by the reaction of lectins, weak aggregation with polybrene, and low sialic acid levels of red cell. This change of red cell membrane was thought to be due to somatic mutation at stem cell level. |
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| AbstractList | Polyagglutination of erythrocytes is observed when most normal ABO-compatible human serum agglutinate the tested red cells. Recently we had a case of polyagglutination caused by the Tn antigen. Tn-polyagglutination was detected in the blood of a 78-years-old female patient with pancytopenia. The true blood group of the patient was O, but her cells had an aquired A-like specificity. Confirmation that the polyagglutination was caused by Tn activation was established by the reaction of lectins, weak aggregation with polybrene, and low sialic acid levels of red cell. This change of red cell membrane was thought to be due to somatic mutation at stem cell level. |
| Author | Fujikawa, Yoko Horiuchi, Atsushi Tsujibayashi, Mitsuyo Akiyama, Mitsuko Ashida, Takashi Fujita, Michiko Senoo, Taiko Okubo, Yasuto Kanemitsu, Yasushi Iwanaga, Takauki |
| Author_xml | – sequence: 1 fullname: Tsujibayashi, Mitsuyo organization: Blood Transfusion Service, Kinki University Hospital – sequence: 1 fullname: Iwanaga, Takauki organization: Blood Transfusion Service, Kinki University Hospital – sequence: 1 fullname: Senoo, Taiko organization: Japanese Red Cross Osaka Blood Center – sequence: 1 fullname: Okubo, Yasuto organization: Japanese Red Cross Osaka Blood Center – sequence: 1 fullname: Fujita, Michiko organization: Blood Transfusion Service, Kinki University Hospital – sequence: 1 fullname: Akiyama, Mitsuko organization: Blood Transfusion Service, Kinki University Hospital – sequence: 1 fullname: Horiuchi, Atsushi organization: Blood Transfusion Service, Kinki University Hospital – sequence: 1 fullname: Fujikawa, Yoko organization: Blood Transfusion Service, Kinki University Hospital – sequence: 1 fullname: Kanemitsu, Yasushi organization: Blood Transfusion Service, Kinki University Hospital – sequence: 1 fullname: Ashida, Takashi organization: The Third Department of Internal Medicine, Kinki University |
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| References | 6) Sturgeon, P. D., et al.: Atypical immunological tolerance in a human blood group chimera. Blood, 33: 507-526, 1969. 16) Kourteva, B. T., et al.: Tn polyagglutinability of red blood cells and acquired A-like specificity. Transfusion, 17: 272-276, 1977. 8) Gunson, H. H., et al.: An example of polyagglutinability due to Tn antigen. Br. J. Haematol., 18 (3): 309-316, 1970. 3) Myllyla, G., et al.: Mixed field polyagglutinability of red cells due to Tn antigen. 12th Int. Congress, Blood Transfusion, Moscow, 1969, 194-195. 1) 山口英夫: Polyagglutination と連銭形成. Immunohaematology, 1 (1): 119-123, 1979. 11) Bird, G. W. G., et al.: Persistent mixed-field polyagglutination. Br. J. Haematol., 21: 443-453, 1971. 26) Cartron, J. P., et al.: Demonstration of T-transferase deficiency in Tn-polyagglutinable blood samples. Eur. J. Biochem., 92 (1): 111-120, 1978. 24) Springer, G. F., et al.: Origin of anti-thomsenfriedenreich (T) and Tn agglutinins in man and in white leghorn chicks. Br. J. Haematol., 47: 453-460, 1981. 2) Dausset, J., et al.: Acquired hemolytic anemia with polyagglutinability of red blood cells due to anew facter present in normal human serum (anti-Tn). Blood, 14: 1079-1093, 1959. 15) Bird, G. W. G., et al.: Erythrocyte membrane modification in malignant disease of myeloid and lymporeticular tissues. Br. J. Haematol., 33: 289-294, 1976. 23) 前川勲ほか: Tn抗原陽性による polyagglutination を合併した haemopoietic dysplasia の一剖検例. Immunohaematology, 4 (2): 228-234, 1982. 4) Van der Hart, M., et al.: Asecond example of red cell polyagglutinability caused by the Tn antigen. Vox Sang, 6: 358-361, 1961. 5) Freiesleben, E., et al.: Permanent mixed field polyagglutinability. Proc. 8th Congr. Europ. Soc. Hematol, Wien, 1962, 506. 12) Berman, H. J., et al.: Tn activation with acquired A-like antigen. Transfusion, 12: 35-45, 1972. 9) Haynes, C. R., et al.: Persistent polyagglutinability in vivo unrelated to T-antigen activation. Transfusion, 10: 43-51, 1970. 21) William, V., et al.: Clonal expression of the Tn antigen in erythroid and granulocyte cdonies and its application to determination of the clonality of the human magakaryocyte colony assay. J. Clin. Invest., 69 (5): 1081-1091, 1982. 27) Beck, M. L., et al.: Observations on leucocytes and platelets in six cases of Tn-polyagglutination. Med. Lab. Sci., 34: 325-329, 1977. 13) Sturgeon, P. D., et al.: Permanent mixed-field polyagglutinability serological observations. Vox Sang, 25: 481-497, 1973. 19) Michael, L. B., et al.: Tn-polyagglutinability associated with acute myelomonocytic leukemia. A. J. C. P., 72 (6): 1024-1027, 1979. 22) 高島国晴ほか: Polyagglutinability を示した Tn-receptor の1例について. 臨床病理, 24 (Suppl.): 519, 1976. 17) JiJi, R. M., et al.: Tn activation with aquired A-like antigen associated with pancytopenia and “ringed” sideroblasts. Abstracts, 26th Annual Meeting, American Association of Blood Banks, 1973, 112. 14) Issitt, P. D., et al.: Applied Blood Group Serology. Second edition. Spectra Biologicals, Oxnard, California, 1977, 264. 7) Myllyla, G., et al.: Persistent mixed field polyagglutinability: Electrokinetic and serological aspects. Vox Sang, 20 (1): 7-23, 1971. 10) Gunson, H. H., et al.: The electrophoretic mobility of Tn polyagglutinable erythrocytes. Vox Sang, 21: 455-461, 1971. 20) Lahamann, N., et al.: Anadditional case of antigen Tn polyagglutination. Folia Haematol., 106 (3): 426-434, 1979. 25) Ellisor, S. S.: Seminar on Antigen-Antibody Reactions Revisited. AABB, Anahein, 1982. 18) Ness, P. M., et al.: Tn-polyagglutination precending acute leukemia. Abstracts of Volunteer Papers, 30th Annual Meeting, American Association of Blood Banks, Atlanta, Georgia, 1977. |
| References_xml | – reference: 9) Haynes, C. R., et al.: Persistent polyagglutinability in vivo unrelated to T-antigen activation. Transfusion, 10: 43-51, 1970. – reference: 16) Kourteva, B. T., et al.: Tn polyagglutinability of red blood cells and acquired A-like specificity. Transfusion, 17: 272-276, 1977. – reference: 1) 山口英夫: Polyagglutination と連銭形成. Immunohaematology, 1 (1): 119-123, 1979. – reference: 25) Ellisor, S. S.: Seminar on Antigen-Antibody Reactions Revisited. AABB, Anahein, 1982. – reference: 27) Beck, M. L., et al.: Observations on leucocytes and platelets in six cases of Tn-polyagglutination. Med. Lab. Sci., 34: 325-329, 1977. – reference: 21) William, V., et al.: Clonal expression of the Tn antigen in erythroid and granulocyte cdonies and its application to determination of the clonality of the human magakaryocyte colony assay. J. Clin. Invest., 69 (5): 1081-1091, 1982. – reference: 10) Gunson, H. H., et al.: The electrophoretic mobility of Tn polyagglutinable erythrocytes. Vox Sang, 21: 455-461, 1971. – reference: 12) Berman, H. J., et al.: Tn activation with acquired A-like antigen. Transfusion, 12: 35-45, 1972. – reference: 18) Ness, P. M., et al.: Tn-polyagglutination precending acute leukemia. Abstracts of Volunteer Papers, 30th Annual Meeting, American Association of Blood Banks, Atlanta, Georgia, 1977. – reference: 24) Springer, G. F., et al.: Origin of anti-thomsenfriedenreich (T) and Tn agglutinins in man and in white leghorn chicks. Br. J. Haematol., 47: 453-460, 1981. – reference: 14) Issitt, P. D., et al.: Applied Blood Group Serology. Second edition. Spectra Biologicals, Oxnard, California, 1977, 264. – reference: 2) Dausset, J., et al.: Acquired hemolytic anemia with polyagglutinability of red blood cells due to anew facter present in normal human serum (anti-Tn). Blood, 14: 1079-1093, 1959. – reference: 5) Freiesleben, E., et al.: Permanent mixed field polyagglutinability. Proc. 8th Congr. Europ. Soc. Hematol, Wien, 1962, 506. – reference: 15) Bird, G. W. G., et al.: Erythrocyte membrane modification in malignant disease of myeloid and lymporeticular tissues. Br. J. Haematol., 33: 289-294, 1976. – reference: 3) Myllyla, G., et al.: Mixed field polyagglutinability of red cells due to Tn antigen. 12th Int. Congress, Blood Transfusion, Moscow, 1969, 194-195. – reference: 19) Michael, L. B., et al.: Tn-polyagglutinability associated with acute myelomonocytic leukemia. A. J. C. P., 72 (6): 1024-1027, 1979. – reference: 7) Myllyla, G., et al.: Persistent mixed field polyagglutinability: Electrokinetic and serological aspects. Vox Sang, 20 (1): 7-23, 1971. – reference: 17) JiJi, R. M., et al.: Tn activation with aquired A-like antigen associated with pancytopenia and “ringed” sideroblasts. Abstracts, 26th Annual Meeting, American Association of Blood Banks, 1973, 112. – reference: 22) 高島国晴ほか: Polyagglutinability を示した Tn-receptor の1例について. 臨床病理, 24 (Suppl.): 519, 1976. – reference: 23) 前川勲ほか: Tn抗原陽性による polyagglutination を合併した haemopoietic dysplasia の一剖検例. Immunohaematology, 4 (2): 228-234, 1982. – reference: 4) Van der Hart, M., et al.: Asecond example of red cell polyagglutinability caused by the Tn antigen. Vox Sang, 6: 358-361, 1961. – reference: 20) Lahamann, N., et al.: Anadditional case of antigen Tn polyagglutination. Folia Haematol., 106 (3): 426-434, 1979. – reference: 8) Gunson, H. H., et al.: An example of polyagglutinability due to Tn antigen. Br. J. Haematol., 18 (3): 309-316, 1970. – reference: 11) Bird, G. W. G., et al.: Persistent mixed-field polyagglutination. Br. J. Haematol., 21: 443-453, 1971. – reference: 6) Sturgeon, P. D., et al.: Atypical immunological tolerance in a human blood group chimera. Blood, 33: 507-526, 1969. – reference: 13) Sturgeon, P. D., et al.: Permanent mixed-field polyagglutinability serological observations. Vox Sang, 25: 481-497, 1973. – reference: 26) Cartron, J. P., et al.: Demonstration of T-transferase deficiency in Tn-polyagglutinable blood samples. Eur. J. Biochem., 92 (1): 111-120, 1978. |
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| Title | A CASE OF Tn-POLYAGGLUTINATION WITH PANCYTOPENIA |
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