A CASE OF Tn-POLYAGGLUTINATION WITH PANCYTOPENIA

Polyagglutination of erythrocytes is observed when most normal ABO-compatible human serum agglutinate the tested red cells. Recently we had a case of polyagglutination caused by the Tn antigen. Tn-polyagglutination was detected in the blood of a 78-years-old female patient with pancytopenia. The tru...

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Published inJournal of the Japan Society of Blood Transfusion Vol. 30; no. 3; pp. 192 - 198
Main Authors Tsujibayashi, Mitsuyo, Iwanaga, Takauki, Senoo, Taiko, Okubo, Yasuto, Fujita, Michiko, Akiyama, Mitsuko, Horiuchi, Atsushi, Fujikawa, Yoko, Kanemitsu, Yasushi, Ashida, Takashi
Format Journal Article
LanguageJapanese
Published The Japan Society of Transfusion Medicine and Cell Therapy 1984
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ISSN0546-1448
1883-8383
DOI10.3925/jjtc1958.30.192

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Summary:Polyagglutination of erythrocytes is observed when most normal ABO-compatible human serum agglutinate the tested red cells. Recently we had a case of polyagglutination caused by the Tn antigen. Tn-polyagglutination was detected in the blood of a 78-years-old female patient with pancytopenia. The true blood group of the patient was O, but her cells had an aquired A-like specificity. Confirmation that the polyagglutination was caused by Tn activation was established by the reaction of lectins, weak aggregation with polybrene, and low sialic acid levels of red cell. This change of red cell membrane was thought to be due to somatic mutation at stem cell level.
ISSN:0546-1448
1883-8383
DOI:10.3925/jjtc1958.30.192