Incorporation of a new radioactive compound, 4+Sn-117m DTPA, into normal and burred rat femurs

The physical characteristics of a new tin radiopharmaceutical, 4+Sn-117m diethylenetriamine-pentaacetic acid (DTPA), may make this compound appropriate for orthopedic therapeutic application. The physical and biologic half-lives of this tracer are 14 and 7.8 days, respectively. The decay scheme cons...

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Bibliographic Details
Published inClinical orthopaedics and related research no. 206; p. 290
Main Authors Hurst, L C, Badalamente, M A, Oster, Z H, Atkins, H L, Weissberg, D
Format Journal Article
LanguageEnglish
Published United States 01.05.1986
Subjects
Animals
Autoradiography
Bone and Bones - metabolism
Femur - diagnostic imaging
Half-Life
Pentetic Acid - metabolism
Radionuclide Imaging
Rats
Rats, Inbred Strains
Technetium - metabolism
Technetium Tc 99m Pentetate - analogs & derivatives
Wound Healing
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Summary:The physical characteristics of a new tin radiopharmaceutical, 4+Sn-117m diethylenetriamine-pentaacetic acid (DTPA), may make this compound appropriate for orthopedic therapeutic application. The physical and biologic half-lives of this tracer are 14 and 7.8 days, respectively. The decay scheme consists of short-range tissue destroying beta, conversion, and Auger electrons, and a 159-keV gamma ray. Significantly, this compound has a high degree of affinity for newly calcified bone at the site of experimental burr holes in contrast to the adjacent bone marrow. Radioactive skeletal retention was one-half of whole body retention.
ISSN:0009-921X
DOI:10.1097/00003086-198605000-00048