Pre-operative thyroglobulin measurement for thyroid cancer risk of recurrence and response to therapy
Thyroid cancer has an overall favorable prognosis, but no pre-operative biochemical marker has been shown to distinguish between low and high-risk disease or predict response to therapy. We retrospectively reviewed 162 patients that underwent thyroid surgery for thyroid cancer between 2006 and 2022...
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Published in | The American journal of surgery p. 115818 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
03.07.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Thyroid cancer has an overall favorable prognosis, but no pre-operative biochemical marker has been shown to distinguish between low and high-risk disease or predict response to therapy.
We retrospectively reviewed 162 patients that underwent thyroid surgery for thyroid cancer between 2006 and 2022 in whom a pre-operative thyroglobulin level (Tg) was measured. We subdivided patients into low, intermediate and high-risk thyroid cancer and based on their response to therapy per ATA guidelines.
We showed that as pre-operative Tg level increased, patients were more likely to have high-risk disease (p < 0.01). We found a linear association between the primary tumor size and high-risk histology with pre-operative Tg (p < 0.01). Pre-operative Tg level was significantly associated with response to therapy following initial surgical management. Specifically, as pre-operative Tg increases, patients were less likely to achieve an excellent response (p < 0.01).
Our retrospective analysis demonstrated that pre-operative Tg is significantly associated with ATA structural risk of recurrence and response to therapy and may have the potential to guide initial therapy and follow-up management.
•Pre-operative Tg is independently associated with tumor size and aggressive histology•The lower the pre-operative Tg, the more likely the patient will have an excellent response to therapy following initial surgical management•Specifically, a low pre-operative Tg, age, and number of metastatic lymph nodes were independently associated with an excellent response to therapy•In addition, a cut off Tg value of 27.0 ng/ml predicted patients with high-risk disease would have an excellent response to therapy |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0002-9610 1879-1883 1879-1883 |
DOI: | 10.1016/j.amjsurg.2024.115818 |