March of the Eosinophils: A Case of Eosinophilic Gastroenteritis, Immune Thrombocytopenia, and Iron Deficiency Anemia

Eosinophilic gastrointestinal disorders (EGIDs) refer to eosinophilic infiltration of various sections of the gastrointestinal tract in the absence of secondary causes. Diagnosis of EGID requires histological evidence of eosinophilic infiltration of the GI tract. Here, we present a case of a young m...

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Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 14; no. 9
Main Authors Singh, Gurdeep, Farooq, Aimen, Mian, Arooj, Bani Fawwaz, Baha Aldeen, Gerges, Peter, Khan, Abu H
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 05.09.2022
Cureus
Subjects
Abdomen
Allergy/Immunology
Anemia
Biopsy
Case reports
Diet
Endoscopy
Esophagus
Food allergies
Gastroenteritis
Gastroenterology
Hay fever
Inflammation
Iron
Literature reviews
Pathology
Patients
Purpura
Rhinitis
Small intestine
Stomach
Surveillance
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Summary:Eosinophilic gastrointestinal disorders (EGIDs) refer to eosinophilic infiltration of various sections of the gastrointestinal tract in the absence of secondary causes. Diagnosis of EGID requires histological evidence of eosinophilic infiltration of the GI tract. Here, we present a case of a young male with biopsy-proven eosinophilic gastroenteritis with a concomitant established diagnosis of immune thrombocytopenic purpura (ITP). Presently, EGIDs remain an underexplored clinical entity. While its pathophysiology is not fully understood at this time, TH2 mediated activation of B-cells and subsequent stimulation of eosinophils locally appears to be at play. This is in contrast to the TH1 predominant cytokine profile underlying ITP, which this patient also has. Treatment typically involves dietary modifications and glucocorticoids.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.28814