Long-term predominance in childhood colonization of the multidrug-resistant lineage 6C/ST386 of Streptococcus pneumoniae after universal immunization with the 10-valent pneumococcal conjugate vaccine in Brazil

• Published in: Vaccine Vol. 42; no. 26; p. 126414
• Main Authors: Miranda, Filipe M., da Silva, Lívia D., Fortuna, Letícia B.D.P., Silva, Amanda B., Cabral, Amanda S., Lima, Jailton L.C., Vieira, Carmen B., Teixeira, Lúcia M., de Souza, Aline R.V., Neves, Felipe P.G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 02.10.2024
• Subjects: Antimicrobial resistance; Pneumococcal conjugate vaccines; Serotypes; Streptococcus pneumoniae; CLI; PCV; TET; CDC; PMEN; CHL; ERY; SXT; MDR; WHO; CC; CLSI; ST; MLST; AMR; MIC; STGG; Streptococcus pneumoniae; Serotypes; PEN; Pneumococcal conjugate vaccines; Antimicrobial resistance; IPD; PCR; PNSP
• ISSN: 0264-410X; 1873-2518; 1873-2518
• DOI: 10.1016/j.vaccine.2024.126414

A study conducted in the city of Niterói/RJ, four years after the introduction of the pneumococcal conjugate vaccine in Brazil, reported the emergence of non-vaccine serotype 6C Streptococcus pneumoniae associated with carriage in children. The multidrug-resistant (MDR) lineage ST386 was predominant among 6C isolates. A subsequent study, in 2019, reported the continued prevalence of 6C as the main serotype. This study aims to determine the genetic lineages of serotype 6C S. pneumoniae obtained from the 2019 study and evaluate the status of ST386 in this population. Serotype 6C S. pneumoniae isolates were obtained during the 2019 study. Lineages were determined by MLST and changes in ST386 status between 2014 and 2019 were verified by a two-tailed Fisher's exact test. Of the 16 serotype 6C isolates recovered during 2019, 10 (62.5 %) belonged to ST386, remaining predominant in the population. The second most frequent was ST2777 represented by four (25 %) isolates. Both ST63 and ST3280 only had one (6.25 %) isolate each. Comparison of ST386 proportion between 2014 and 2019 showed no significant changes within the population. This study was able to confirm the stability on the occurrence of the MDR lineage ST386 in children in our setting nine years after the introduction of PCV10 in Brazil.