Molecular mechanisms of appetite control via 5-HT1B receptors

To prevent this, AgRP neurons send inhibitory synapses to POMC neurons utilizing g-aminobutyric acid (GABA) as a neurotransmitter. [...]when AgRP neurons are active and stimulate hunger, they also inhibit satiety POMC neurons. In our work we studied the impact of serotonin 1B metabotropic receptors...

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Bibliographic Details
Published inProceedings of the Nutrition Society Vol. 81; no. OCE1
Main Authors Martinez de Morentin, P.B., Heisler, L.K., Sylantyev, S.
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 2022
Subjects
Appetite
Calcium channels
Calcium channels (voltage-gated)
Calcium ions
Feeding behavior
Hippocampus
Hunger
Metabotropic receptors
Molecular modelling
Neurons
Neurotransmitter release
Neurotransmitters
Proopiomelanocortin
Receptors
Satiety
Serotonin
Serotonin S1 receptors
Synapses
γ-Aminobutyric acid
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Summary:To prevent this, AgRP neurons send inhibitory synapses to POMC neurons utilizing g-aminobutyric acid (GABA) as a neurotransmitter. [...]when AgRP neurons are active and stimulate hunger, they also inhibit satiety POMC neurons. In our work we studied the impact of serotonin 1B metabotropic receptors (5-HT1BRs) on inhibitory signalling in AgRP→POMC synapses. 5-HT1BRs are involved into regulation of feeding behaviour, inhibit AgRP neurons and disinhibit POMC neurons(1,2). [...]5-HT1BRs impact neurotransmitter release in synapses via downregulation of voltage-gated Ca2+ channels (VGCCs) in hippocampal neurons(3). [...]we set out to clarify if 5-HT1BRs regulate the level of inhibition of POMC neurons by AgRP cells and, if yes, whether this is due to 5-HT1BRs impact on VGCCs.
ISSN:0029-6651
1475-2719
DOI:10.1017/S002966512200026X