Back Cover: A Giant Heterometallic Polyoxometalate Nanocluster for Enhanced Brain‐Targeted Glioma Therapy (Angew. Chem. Int. Ed. 10/2024)

Giant heterometallic polyoxometalate (POM) clusters own flexibly adjustable active sites and are promising functional drug carriers. In their Research Article (e202319700), Jiefei Wang, Bingyang Shi, Junwei Zhao et al. designed the largest (3.0 nm × 6.0 nm) Ce3+/Ag+ co‐encapsulated POM cluster with...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 63; no. 10
Main Authors Song, Nizi, Lu, Mengya, Liu, Jiancai, Lin, Ming, Shangguan, Ping, Wang, Jiefei, Shi, Bingyang, Zhao, Junwei
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 04.03.2024
EditionInternational ed. in English
Subjects
Apoptosis
Blood-brain barrier
Brain
Cerium
Drug carriers
Drug delivery
Glioma
Nanoclusters
Polyoxometallates
Reactive oxygen species
Online AccessGet full text

Cover

More Information
Summary:Giant heterometallic polyoxometalate (POM) clusters own flexibly adjustable active sites and are promising functional drug carriers. In their Research Article (e202319700), Jiefei Wang, Bingyang Shi, Junwei Zhao et al. designed the largest (3.0 nm × 6.0 nm) Ce3+/Ag+ co‐encapsulated POM cluster with blood brain barrier‐traversing and mitochondrial targeting properties to solve the long‐standing brain delivery problem of drugs for glioma. As the first brain‐targeting POM drug, Ag+ specifically activates reactive oxygen species regulated apoptosis pathway of glioma and efficiently prolongs the survival of orthotopic glioma‐bearing mice.
Bibliography:These authors contributed equally to this work.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202402319