Pregnancy vitamin D supplementation leads to greater offspring bone mineral density at age 4 years: findings from the MAVIDOS trial

• Published in: Proceedings of the Nutrition Society Vol. 80; no. OCE5
• Main Authors: Curtis, E.M., Moon, R.J., D'Angelo, S., Crozier, S.R., Bishop, N.J., Gopal-Kothandapani, J.S., Kennedy, S.H., Papageorghiou, A.T., Fraser, R., Gandhi, S.V., Schoenmakers, I., Prentice, A., Inskip, H.M., Godfrey, K.M., Javaid, M.K., Eastell, R., Cooper, C., Harvey, N.C.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 2021
• Subjects: Age; Anthropometry; Biomarkers; Biomedical materials; Biomedical research; Bone density; Bone mass; Bone mineral content; Bone mineral density; Calciferol; Dietary supplements; Dual energy X-ray absorptiometry; Nutrition; Offspring; Osteoporosis; Placebos; Pregnancy; Vitamin D; United Kingdom > UK
• ISSN: 0029-6651; 1475-2719
• DOI: 10.1017/S0029665121003104

At age 4 years (Southampton participants only, n = 723 births), offspring assessments included anthropometry and whole-body dual-energy x-ray absorptiometry (DXA) [Hologic Horizon, yielding whole body less head (WBLH) bone mineral content (BMC), areal bone mineral density (aBMD), bone area (BA) and lean mass (LM)]. Maternal pregnancy vitamin D supplementation led to greater offspring indices of bone mass compared with placebo, irrespective of season, for example WBLH aBMD at age 4 years, [supplemented group, 0.477 (95% CI: 0.472,0.481) g/cm2; placebo group 0.470 (0.466,0.475) g/cm2; β=0.18 (0.00,0.35) SD p = 0.047], and a trend towards associated greater LM [supplemented group, 9.25 (9.08,9.42) kg; placebo group 9.01 (8.83,9.18) kg; β=0.15 (-0.02, 0.31) SD p = 0.081]. The work leading to these results was supported by the UK Royal Osteoporosis Society Osteoporosis and Bone Research Academy, the European Union's Seventh Framework Programme (FP7/2007–2013), projects EarlyNutrition and ODIN under grant agreements numbers 289346 and 613977, and by the BBSRC (HDHL-Biomarkers, BB/P028179/1), as part of the ALPHABET project, supported by an award made through the ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL), Horizon 2020 grant agreement number 696295.