A “Bridge‐Building” Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization (Adv. Mater. 42/2021)

In Situ Endothelialization In article number 2103490, Lei Dong, Chunming Wang, and co‐workers describe how fungal sugars in bioscaffold design are mimicked to support vascular growth. When microbes invade human tissue, their surface carbo hydrates bridge the endothelium for further transmigration. G...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 33; no. 42
Main Authors Mu, Ruoyu, Zhang, Yuhan, Yan, Lingli, Liao, Zhencheng, Yang, Yushun, Su, Huanxing, Dong, Lei, Wang, Chunming
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.10.2021
Subjects
angiogenesis
blood vessels
carbohydrates
cell adhesion
Endothelial cells
Endothelium
Glycan
Human tissues
Hydrates
Materials science
Microorganisms
natural biomaterials
Scaffolds
Sugar
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Summary:In Situ Endothelialization In article number 2103490, Lei Dong, Chunming Wang, and co‐workers describe how fungal sugars in bioscaffold design are mimicked to support vascular growth. When microbes invade human tissue, their surface carbo hydrates bridge the endothelium for further transmigration. Glucomannans are chemically modified and electrospun into a fibrous scaffold, which recruits galectins to bridge endothelial cells with the scaffold. This helps to recover blood perfusion in a murine ischemic model.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202170334