Risk of fatal and non-fatal cardiovascular events in men aged 25-44 in the city of Novosibirsk. Cohort study

• Published in: Kardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika Vol. 22; no. 1; p. 3393
• Main Authors: Stryukova, E. V., Shcherbakova, L. V., Gafarov, V. V., Rymar, O. D., Khudyakova, A. D., Evdokimova, N. E., Ragino, Yu. I.
• Format: Journal Article
• Language: English; Russian
• Published: SILICEA-POLIGRAF» LLC 01.02.2023
• Subjects: артериальная гипертензия; глюкоза крови; когортное исследование; креатинин; сердечно-сосудистые события; частота сердечных сокращений
• ISSN: 1728-8800; 2619-0125
• DOI: 10.15829/1728-8800-2023-3393

Aim. To study the incidence and risk factors of cardiovascular events (CVEs) during an 8-year follow-up of a cohort of men aged 25-44 years (Novosibirsk). Material and methods . The cohort study included 1415 people aged 37,33 [31,83; 41,92] years (Median, Me [interquartile range, Q25; Q75], of which 670 (47,3%) were men. Median follow-up period was 6,9 [5,8; 7,8] years. CVEs were identified using the "Registry of Acute Myocardial Infarction", fatal cases — from the "Medical Certificates of Cause of Death". The examination program included a questionnaire, anthropometry, biochemical studies. Statistical processing was carried out using SPSS (version 13.0). Results. Thirteen CVEs were identified, of which 6 were fatal. Survival prognosis was more favorable in men without hypertension, with a heart rate (HR) <80 bpm. The risk of CVEs increased by 14% with an increase in fasting plasma glucose by 0,5 mmol/l, by 1,8 times with creatinine increase by 10 pmol/l (decreased by 29% with an increase in glomerular filtration rate by 5 ml/min /1,73 m 2 ); 2 times with a heart rate increase by 10 bpm, regardless of other cardiometabolic risk factors. Conclusion. Significant risk factors for fatal and non-fatal CVEs in men aged 25-44 years are hypertension, heart rate >80 bpm, increased fasting plasma glucose, creatinine levels (or decreased glomerular filtration rate).