Habitual protein intake appears to modulate postprandial muscle protein synthesis responses to feeding in youth but not in older age

Sarcopenia, defined as an age-related loss of muscle mass and function, is a key contributing factor to frailty, a syndrome with prominent impact on maintenance of physical independence(2). Anabolic resistance, the blunted MPS response of skeletal muscle to key anabolic stimuli, namely essential ami...

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Bibliographic Details
Published inProceedings of the Nutrition Society Vol. 80; no. OCE1
Main Authors Mathewson, S L., Gordon, A L., Smith, K., Atherton, P J., Greig, C A., Phillips, B E.
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 2021
Subjects
Absorptivity
Age
Amino acids
Leucine
Metabolic rate
Metabolism
Muscles
Musculoskeletal system
Nutrition
Nutrition research
Older people
Protein biosynthesis
Protein synthesis
Proteins
Sarcopenia
Skeletal muscle
Spectrometry
Stable isotopes
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Summary:Sarcopenia, defined as an age-related loss of muscle mass and function, is a key contributing factor to frailty, a syndrome with prominent impact on maintenance of physical independence(2). Anabolic resistance, the blunted MPS response of skeletal muscle to key anabolic stimuli, namely essential amino acid (EAA) nutrition(3), has been demonstrated in older individuals. [...]it is likely that anabolic resistance contributes to sarcopenia progression. Post-absorptive MPS and MPS in response to mixed macronutrient feeding (4.25x basal metabolic rate; 16% protein) was determined from muscle biopsies of the m. vastus lateralis (VL) via stable isotope tracer ([1, 2–13C2]-leucine) infusions paired with mass-spectrometric analyses.
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665121000033