TfR Aptamer Enhanced Blood‐Brain Barrier Penetration of Biomimetic Nanocomplexes for Intracellular Transglutaminase 2 Imaging and Silencing in Glioma (Small 40/2022)

Brain Tumor Theranostics In article number 2203448, Hongping Xia, Songqin Liu, Yafeng Wu, and co‐workers prepare dual blood–brain barrier (BBB) targeting biomimetic nanocomplexes (TMPsM) for simultaneous accurate diagnosis and effective treatment of glioma. The biomimetic outer shells endow them wit...

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Bibliographic Details
Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 18; no. 40
Main Authors Su, Juan, Yao, Zhipeng, Chen, Zixuan, Zhou, Sisi, Wang, Zhi, Xia, Hongping, Liu, Songqin, Wu, Yafeng
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.10.2022
Subjects
aggregation‐induced emission (AIE) fluorescence imaging
biomimetic nanocomplexes
Biomimetics
Blood-brain barrier
boosted targeting capability
glioma
Medical imaging
Nanotechnology
Penetration
siRNA delivery
Tumors
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Summary:Brain Tumor Theranostics In article number 2203448, Hongping Xia, Songqin Liu, Yafeng Wu, and co‐workers prepare dual blood–brain barrier (BBB) targeting biomimetic nanocomplexes (TMPsM) for simultaneous accurate diagnosis and effective treatment of glioma. The biomimetic outer shells endow them with enhanced BBB penetration and ensure the delivery of theranostic agents into brain tumor sites for single intracellular transglutaminase 2‐triggered self‐assembly aggregation‐induced emission imaging and RNAi therapy.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202270212