Commentary on Essential roles of PI(3)K-p110β in cell growth, metabolism, and tumorigenesis

• Published in: Urologic oncology Vol. 27; no. 2; pp. 228 - 229
• Main Author: Huang, Haojie, Ph.D
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 2009
• Subjects: Urology

On activation by receptors, the ubiquitously expressed class IA isoforms (p110α and p110β) of phosphatidylinositol-3-OH kinase (PI(3)K) generate lipid second messengers, which initiate multiple signal transduction cascades. Recent studies have demonstrated specific functions for p110α in growth fact...