An experimental study of lung lesions caused by extracellular enzyme of Streptomyces thermohygroscopicus

Rabbits and rats were infected intratracheally with extracellular enzyme of Streptomyces thermohygroscopicus (H9-4) by only one exposure, and lesions of the lung developed including mononuclear macrophage infiltration as well as bronchitis and vasculitis. The obvious damages in type I pneumocytes, e...

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Bibliographic Details
Published inJournal of Tongji Medical University Vol. 11; no. 1; p. 10
Main Authors Huang, X Z, Che, D Y
Format Journal Article
LanguageEnglish
Published China 01.03.1991
Subjects
Animals
Farmer's Lung - chemically induced
Farmer's Lung - pathology
Female
Fibronectins - metabolism
Lung - metabolism
Lung - ultrastructure
Male
Rabbits
Rats
Rats, Inbred Strains
Streptomyces - enzymology
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Summary:Rabbits and rats were infected intratracheally with extracellular enzyme of Streptomyces thermohygroscopicus (H9-4) by only one exposure, and lesions of the lung developed including mononuclear macrophage infiltration as well as bronchitis and vasculitis. The obvious damages in type I pneumocytes, endothelial cells of capillaries and arterioles in the lung were observed by electron microscopy. Immunofluorescent histochemistry examination revealed exudation of plasma fibronectin which might play an important role during the process of lesion repairing in lung. The experiment also confirmed that extracellular enzyme of Streptomyces thermohygroscopicus might directly damage the lung tissue. These experimental data may serve as valuable reference for studying the etiology and pathogenesis of farmer's lung disease.
ISSN:0257-716X
DOI:10.1007/BF02893180