Concerted contractions of tumour fragments derived from a pure mucoid carcinoma of the breast in vitro

Organized tissue fragments obtained by dissociation of a pure mucoid carcinoma of the breast were cultured in vitro. The cellular organization of the fragments appears similar to that observed in vivo, and consist of mucous-filled spherules surrounded by a single layer of tumour cells. Time-lapse vi...

Full description

Saved in:
Bibliographic Details
Published inJournal of cancer research and clinical oncology Vol. 114; no. 5; p. 523
Main Authors van Netten, J P, Racca, R L, Ashwood-Smith, M J, Armstrong, J, Fletcher, C, Goodchild, N L
Format Journal Article
LanguageEnglish
Published Germany 01.10.1988
Subjects
Adenocarcinoma, Mucinous - pathology
Breast Neoplasms - pathology
Female
Humans
Tumor Cells, Cultured
Online AccessGet more information

Cover

More Information
Summary:Organized tissue fragments obtained by dissociation of a pure mucoid carcinoma of the breast were cultured in vitro. The cellular organization of the fragments appears similar to that observed in vivo, and consist of mucous-filled spherules surrounded by a single layer of tumour cells. Time-lapse video recordings revealed that the cells surrounding these fragments undergo a concerted contraction and relaxation over the time span of several hours. The presence of cytokeratin and oestrogen receptors in the cells suggests an epithelial derivation. Movement of tumour fragments of the type described here could potentially influence the metastatic process of some breast cancers.
ISSN:0171-5216
DOI:10.1007/BF00391505