Lymphocyte reactivity in Imuran-treated guinea-pigs and in vitro effect of colchicine

Imuran treatment significantly diminished macrophage migration inhibition in immunized guinea-pigs and the percentage of E-rosette forming cells in all treated animals. 10(-6) M colchicine in vitro significantly increased the percentage of E-rosette forming cells in Imuran-treated animals. The resul...

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Bibliographic Details
Published inExperientia Vol. 37; no. 5; p. 519
Main Authors Milosević, D, Sami, I, Stanojević-Bakić, N, Spuzić, I
Format Journal Article
LanguageEnglish
Published Switzerland 15.05.1981
Subjects
Animals
Azathioprine - pharmacology
Cell Migration Inhibition
Colchicine - pharmacology
Guinea Pigs
Lymphocytes - drug effects
Lymphocytes - immunology
Macrophages - drug effects
Macrophages - immunology
Rosette Formation
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Summary:Imuran treatment significantly diminished macrophage migration inhibition in immunized guinea-pigs and the percentage of E-rosette forming cells in all treated animals. 10(-6) M colchicine in vitro significantly increased the percentage of E-rosette forming cells in Imuran-treated animals. The results suggest possible alteration of the lymphocyte receptors after treatment with Imuran.
ISSN:0014-4754
DOI:10.1007/BF01986173