Effect of NF‐κB on Myosin Heavy Chain Content and Muscle Atrophy After Laryngeal Muscle Denervation

Significant findings of the study: We found that inhibiting NF‐κB could delay MyHC degradation and muscle atrophy in denervated laryngeal muscles, but the effect cannot be sustained. This finding suggests the possible mechanism of NF‐κB involved in the denervated atrophy of internal laryngeal muscle...

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Bibliographic Details
Published inWorld journal of otorhinolaryngology - head and neck surgery
Main Authors Yang, Jing‐Jing, Hu, Rong, Wang, Hai‐Zhou, Li, Xue‐Yan, Xu, Wen
Format Journal Article
LanguageEnglish
Published 09.03.2025
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Summary:Significant findings of the study: We found that inhibiting NF‐κB could delay MyHC degradation and muscle atrophy in denervated laryngeal muscles, but the effect cannot be sustained. This finding suggests the possible mechanism of NF‐κB involved in the denervated atrophy of internal laryngeal muscles. What this study adds: The study explains the dynamic changes of the internal laryngeal muscle atrophy within 14 days of denervation and the possible mechanism of NF‐κB involved in this process.
ISSN:2095-8811
2589-1081
DOI:10.1002/wjo2.70007