Relation of renal thromboxane A2 production to urine flow, electrolyte excretion and plasma renin activity in control state and drug induced hypotension

The functional importance of renal TxB2 generation in the maintenance of elevated arterial blood pressure in essential hypertension was followed in 22 patients, using the method of sustained blood pressure decrease by i.v. sodium nitroprusside infusion. Linear correlation between urinary excretion o...

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Bibliographic Details
Published inInternational urology and nephrology Vol. 20; no. 2; p. 183
Main Authors Székács, B, Mohácsi, E, Gachályi, B, Tihanyi, K, Juhász, I
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.1988
Subjects
Adult
Blood Pressure
Diuresis
Humans
Hypotension - blood
Hypotension - urine
Middle Aged
Renin - blood
Sodium - urine
Thromboxane A2 - urine
Urodynamics
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Summary:The functional importance of renal TxB2 generation in the maintenance of elevated arterial blood pressure in essential hypertension was followed in 22 patients, using the method of sustained blood pressure decrease by i.v. sodium nitroprusside infusion. Linear correlation between urinary excretion of TxB2, urine flow, and sodium excretion could be established in both control and hypotensive periods. Presumably, changes in urinary excretion of TxB2 reflect a secondary intrarenal counterregulatory response.
ISSN:0301-1623
DOI:10.1007/BF02550670