Measurement of portal vascular resistance in patients with chronic liver diseases by simultaneous measurement of portal blood flow and portal venous pressure
We measured the portal vascular resistance in 65 cases percutaneously. The portal vascular resistance (PVR) was calculated from the portal blood flow (PBF), portal venous pressure (PVP) and the hepatic venous pressure (HVP), all of which were measured simultaneously. The PVR was calculated by the eq...
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| Published in | Kanzo Vol. 26; no. 4; pp. 485 - 492 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Hepatology
1985
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| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.26.485 |
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| Abstract | We measured the portal vascular resistance in 65 cases percutaneously. The portal vascular resistance (PVR) was calculated from the portal blood flow (PBF), portal venous pressure (PVP) and the hepatic venous pressure (HVP), all of which were measured simultaneously. The PVR was calculated by the equation PVR=PVP-HVP/PBF. The PBF was measured by an ultrasonic duplex system composed of a real-time B-mode scanner and a pulsed Doppler flowmeter. The PVP was measured by percutaneous transhepatic catheterization under ultrasonic guidance and the HVP was measured by venous catheterization. The PVR was 0.25 ± 0.13 mmHg·ml-1·min·kg (mean ± S.D., n=5) in control subjects, 0.64 ± 0.29 (n=17) in chronic active hepatitis, 1.33 ± 0.79 (n=30) in cirrhosis, and 0.84 ±0.69 (n=13) in idiopathic portal hypertension. By measuring the PVR, we can estimate intrahepatic changes quantitatively which cause portal hypertension. |
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| AbstractList | We measured the portal vascular resistance in 65 cases percutaneously. The portal vascular resistance (PVR) was calculated from the portal blood flow (PBF), portal venous pressure (PVP) and the hepatic venous pressure (HVP), all of which were measured simultaneously. The PVR was calculated by the equation PVR=PVP-HVP/PBF. The PBF was measured by an ultrasonic duplex system composed of a real-time B-mode scanner and a pulsed Doppler flowmeter. The PVP was measured by percutaneous transhepatic catheterization under ultrasonic guidance and the HVP was measured by venous catheterization. The PVR was 0.25 ± 0.13 mmHg·ml-1·min·kg (mean ± S.D., n=5) in control subjects, 0.64 ± 0.29 (n=17) in chronic active hepatitis, 1.33 ± 0.79 (n=30) in cirrhosis, and 0.84 ±0.69 (n=13) in idiopathic portal hypertension. By measuring the PVR, we can estimate intrahepatic changes quantitatively which cause portal hypertension. |
| Author | NAKAMURA, Takefumi OCHI, Jiroh SAKAI, Masahiko BAN, Nobuyuki UCHINO, Haruto SOH, Yasunari MIYAKE, Takeo MORIYASU, Fuminori NISHIDA, Osamu MIURA, Kensuke TSUKADA, Hideaki |
| Author_xml | – sequence: 1 fullname: TSUKADA, Hideaki organization: The Department of Geriatrics, Kyoto University – sequence: 1 fullname: BAN, Nobuyuki organization: The First Department of Internal Medicine, Kyoto University – sequence: 1 fullname: OCHI, Jiroh organization: The First Department of Internal Medicine, Kyoto University – sequence: 1 fullname: SAKAI, Masahiko organization: The First Department of Internal Medicine, Kyoto University – sequence: 1 fullname: NISHIDA, Osamu organization: The First Department of Internal Medicine, Kyoto University – sequence: 1 fullname: NAKAMURA, Takefumi organization: The First Department of Internal Medicine, Kyoto University – sequence: 1 fullname: MIYAKE, Takeo organization: The Department of Geriatrics, Kyoto University – sequence: 1 fullname: MIURA, Kensuke organization: The First Department of Internal Medicine, Kyoto University – sequence: 1 fullname: SOH, Yasunari organization: The Department of Internal Medicine, Amagasaki Prefectural Hospital – sequence: 1 fullname: MORIYASU, Fuminori organization: The First Department of Internal Medicine, Kyoto University – sequence: 1 fullname: UCHINO, Haruto organization: The First Department of Internal Medicine, Kyoto University |
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| References | 10) Sherlock S: Classification and function aspects of portal hypertension. Am J Surg 127: 121-128, 1974 11) Reynolds FB, Ito S, Iwatsuki S: Measurement of portal pressure and its clinical application. Am J Surg 49: 649-659, 1970 16) Okuda K, Nakashima T, Okudaira M,: Liver pathology of idiopathic portal hypertension. Comparison with non-cirrhotic portal fibrosis of India. Liver 12: 176-192, 1982 13) 上原従正:門脈圧亢進症の発生原因に関する研究-とくに類洞狭窄の意義について-.肝臓13: 606-616, 1972 5)森安史典,西田修,伴信之,他:各種肝疾患における門脈血流量の測定-超音波パルスドップラー複合装置による定量的測定-.肝臓26: 208-214, 1985 9) Richardson PDI, Withrington PG: Liver blood flow I. Intrinsic and nervous control of liver blood flow. Gastroenterology 81: 159-173, 1981 1) Gill RW, Kosoff G: Umbilical venous flow in normal and complicated pregnancy. Ultrasound in Med and Biol 10: 349-363, 1984 14) 矢田博之,山本祐三,斉藤雅文,他:類洞性門脈圧亢進-特発性門脈圧亢進症および肝硬変における類洞病変と門脈圧との関係-.大阪医大誌40: 259-265, 1981 8) Shoemaker CP: A study of hepatic hemodynamics in the dog. Circ Res 15: 216-233, 1969 3) Ueda H, Kitani K, Kameda H,: Splenic blood flow in idiopathic portal hypertension in Japan measured by Kr clearance method. Acta Hepato-splenol 18: 28-40, 1971 7) Green HD, Hall LS, Sexton J,: Autonomic vasomotor responses in the canine hepatic arterial and venous beds. Am J Physiol 196: 196-202, 1959 6) Richardson PDI, Withrington PG: Pressureflow relationships and effects of noradrenaline and isoprenaline on the hepatic arterial and portal venous vascular beds of the dog. J Physiol (Lond) 282: 451-470, 1978 12) 松本和基:門脈圧亢進の程度と肝の組織学的変化との関係に関する基礎的研究.肝臓22: 677-689, 1981 2) 森安史典,伴信之,五十嵐昭夫,他:リニア電子スキャン・パルスドップラー複合血流計による門脈血流量測定.肝臓24: 537-544, 1983 4) Koyanagi N, Inokuchi K, Nakayama S,: Decreased arteriovenous flow resistance in the left gastric venous bed in cirrhotic patients. Eur J Clin Invest 11: 355-359, 1981 15) Carter JH, Welch CS, Earron RE: Changes in the hepatic blood vessels in cirrhosis of the liver. Surg Gyn Obst 113: 133-137, 1961 |
| References_xml | – reference: 9) Richardson PDI, Withrington PG: Liver blood flow I. Intrinsic and nervous control of liver blood flow. Gastroenterology 81: 159-173, 1981 – reference: 10) Sherlock S: Classification and function aspects of portal hypertension. Am J Surg 127: 121-128, 1974 – reference: 4) Koyanagi N, Inokuchi K, Nakayama S,: Decreased arteriovenous flow resistance in the left gastric venous bed in cirrhotic patients. Eur J Clin Invest 11: 355-359, 1981 – reference: 11) Reynolds FB, Ito S, Iwatsuki S: Measurement of portal pressure and its clinical application. Am J Surg 49: 649-659, 1970 – reference: 7) Green HD, Hall LS, Sexton J,: Autonomic vasomotor responses in the canine hepatic arterial and venous beds. Am J Physiol 196: 196-202, 1959 – reference: 13) 上原従正:門脈圧亢進症の発生原因に関する研究-とくに類洞狭窄の意義について-.肝臓13: 606-616, 1972 – reference: 2) 森安史典,伴信之,五十嵐昭夫,他:リニア電子スキャン・パルスドップラー複合血流計による門脈血流量測定.肝臓24: 537-544, 1983 – reference: 15) Carter JH, Welch CS, Earron RE: Changes in the hepatic blood vessels in cirrhosis of the liver. Surg Gyn Obst 113: 133-137, 1961 – reference: 3) Ueda H, Kitani K, Kameda H,: Splenic blood flow in idiopathic portal hypertension in Japan measured by Kr clearance method. Acta Hepato-splenol 18: 28-40, 1971 – reference: 8) Shoemaker CP: A study of hepatic hemodynamics in the dog. Circ Res 15: 216-233, 1969 – reference: 1) Gill RW, Kosoff G: Umbilical venous flow in normal and complicated pregnancy. Ultrasound in Med and Biol 10: 349-363, 1984 – reference: 6) Richardson PDI, Withrington PG: Pressureflow relationships and effects of noradrenaline and isoprenaline on the hepatic arterial and portal venous vascular beds of the dog. J Physiol (Lond) 282: 451-470, 1978 – reference: 12) 松本和基:門脈圧亢進の程度と肝の組織学的変化との関係に関する基礎的研究.肝臓22: 677-689, 1981 – reference: 14) 矢田博之,山本祐三,斉藤雅文,他:類洞性門脈圧亢進-特発性門脈圧亢進症および肝硬変における類洞病変と門脈圧との関係-.大阪医大誌40: 259-265, 1981 – reference: 16) Okuda K, Nakashima T, Okudaira M,: Liver pathology of idiopathic portal hypertension. Comparison with non-cirrhotic portal fibrosis of India. Liver 12: 176-192, 1982 – reference: 5)森安史典,西田修,伴信之,他:各種肝疾患における門脈血流量の測定-超音波パルスドップラー複合装置による定量的測定-.肝臓26: 208-214, 1985 |
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| Title | Measurement of portal vascular resistance in patients with chronic liver diseases by simultaneous measurement of portal blood flow and portal venous pressure |
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