Measurement of portal vascular resistance in patients with chronic liver diseases by simultaneous measurement of portal blood flow and portal venous pressure

• Published in: Kanzo Vol. 26; no. 4; pp. 485 - 492
• Main Authors: TSUKADA, Hideaki, BAN, Nobuyuki, OCHI, Jiroh, SAKAI, Masahiko, NISHIDA, Osamu, NAKAMURA, Takefumi, MIYAKE, Takeo, MIURA, Kensuke, SOH, Yasunari, MORIYASU, Fuminori, UCHINO, Haruto
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 1985
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.26.485

We measured the portal vascular resistance in 65 cases percutaneously. The portal vascular resistance (PVR) was calculated from the portal blood flow (PBF), portal venous pressure (PVP) and the hepatic venous pressure (HVP), all of which were measured simultaneously. The PVR was calculated by the equation PVR=PVP-HVP/PBF. The PBF was measured by an ultrasonic duplex system composed of a real-time B-mode scanner and a pulsed Doppler flowmeter. The PVP was measured by percutaneous transhepatic catheterization under ultrasonic guidance and the HVP was measured by venous catheterization. The PVR was 0.25 ± 0.13 mmHg·ml-1·min·kg (mean ± S.D., n=5) in control subjects, 0.64 ± 0.29 (n=17) in chronic active hepatitis, 1.33 ± 0.79 (n=30) in cirrhosis, and 0.84 ±0.69 (n=13) in idiopathic portal hypertension. By measuring the PVR, we can estimate intrahepatic changes quantitatively which cause portal hypertension.