A Study of Guided Tissue Regeneration with a New Fibrous Collagen Membrane Part 1 Development of a New Fibrous Collagen Membrane

• Published in: Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Vol. 33; no. 4; pp. 864 - 871
• Main Authors: KATO, Hiroshi, KUBOKI, Yoshinori, ATSUTA, Tsutomu, OKUGUCHI, Masumi
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY OF PERIODONTOLOGY 1991
• Subjects: Artificial cross-linkage; Cross-linked fibrous collagen membrane; Dialysis; Guided tissue regeneration technique; New attachment
• ISSN: 0385-0110; 1880-408X
• DOI: 10.2329/perio.33.864

The purpose of this study was to develop a biodegradable fibrous collagen membrane in place of the nondegradable membranes currently used for the guided tissue regeneration (GTR) technique. We produced collagen membranes in several ways and examined the velocity of membrane degradation by fundamental experimentation with rats. Firstly, we delayed the velocity of membrane absorption by artificial cross-linkage with hexamethylenediisocyanate (HMDIC) and also tried to control the absorption rate by using different concentrations of HMDIC. As a result, the fibrous collagen membrane treated with 10% HMDIC was not absorbed until 4 weeks after the membrane had been implanted in the back skins of rats. However, findings from examination of membranes implanted in the gingiva at the palatal site of the maxillary right first molars indicated that the membrane was absorbed within 2 weeks of the implantation. Secondly, we developed a cross-linked fibrous collagen membrane the thickened fiber of which was produced by dialysis at 4.. for 48 hrs., and evaluated the absorption of this membrane. The results indicated that the membrane had not been absorbed until 4 weeks after implantation in back skin and 2 weeks after implantation in gingiva. These findings suggest that cross-linked fibrous collagen membranes may have clinical application in the GTR technique.