Thearubigins counteract the toxic effects of botulinum neurotoxins
Type A, B and E botulinum neurotoxins inhibited muscle twitches elicited indirectly in the mouse diaphragm preparations in vitro. Hot water extract of black tea given a mixture with each botulinum toxin protected the inhibitory effect of the toxin. Roasted tea extract was also effective, but not gre...
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Published in | Japanese Journal of Pharmacology Vol. 82; no. suppl.2; p. 282 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Japanese English |
Published |
The Japanese Pharmacological Society
2000
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Online Access | Get full text |
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Summary: | Type A, B and E botulinum neurotoxins inhibited muscle twitches elicited indirectly in the mouse diaphragm preparations in vitro. Hot water extract of black tea given a mixture with each botulinum toxin protected the inhibitory effect of the toxin. Roasted tea extract was also effective, but not green tea, oolong tea, tannic acid, catechins and theaflavins. Extracted thearubigins were effective as such specific antidotes. |
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ISSN: | 0021-5198 1347-3506 |
DOI: | 10.1016/S0021-5198(19)48590-9 |