Thearubigins counteract the toxic effects of botulinum neurotoxins

Type A, B and E botulinum neurotoxins inhibited muscle twitches elicited indirectly in the mouse diaphragm preparations in vitro. Hot water extract of black tea given a mixture with each botulinum toxin protected the inhibitory effect of the toxin. Roasted tea extract was also effective, but not gre...

Full description

Saved in:
Bibliographic Details
Published inJapanese Journal of Pharmacology Vol. 82; no. suppl.2; p. 282
Main Authors Satoh, Eiki, Ishii, Toshiaki, Shimizu, Yoshio, Sawamura, Shin-ichi, Nishimura, Masakazu
Format Journal Article
LanguageJapanese
English
Published The Japanese Pharmacological Society 2000
Online AccessGet full text

Cover

More Information
Summary:Type A, B and E botulinum neurotoxins inhibited muscle twitches elicited indirectly in the mouse diaphragm preparations in vitro. Hot water extract of black tea given a mixture with each botulinum toxin protected the inhibitory effect of the toxin. Roasted tea extract was also effective, but not green tea, oolong tea, tannic acid, catechins and theaflavins. Extracted thearubigins were effective as such specific antidotes.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)48590-9