Age-related changes in ovarian carbonyl reductase of hypercalcitoninemia rats

• Published in: Japanese Journal of Pharmacology Vol. 64; no. suppl.2; p. 288
• Main Authors: Inazu, Norihisa, Fujii, Tomoko
• Format: Journal Article
• Language: Japanese; English
• Published: The Japanese Pharmacological Society 1994
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)50785-5

Rats raised from parathyroid-implanted parents (PT rats) show a significant increase in serum calcitonin as compared with rats raised from sham-operated parents (normal rats). In the present study, age-related changes in ovarian carbonyl reductase (CR) activity in normal and PT rats was investigated. Rats were sacrificed at 5, 8, 10 and 15 months of age. CR activity towards 4 carbonyl compounds in ovarian cytosolic fraction was measured photometrically. Both ovarian weight and ovarian CR activity in PT rats were significantly lower than those in normal rats at each age tested, and PT rats exhibited constant cornified smears at a younger age as compared with normal rats. Although gonadotropin treatment increased the ovarian CR activity in both normal and PT rats as well as the ovarian weight, the stimulatory effect of gonadotropin on PT rats was more potent than that on normal rats. These results suggest that the altered ovarian response to gonadotropin in PT rats may be related to hypercalcitoninemia.