Hereditary C5 Deficiency in Man

Abstract Platelet-rich-plasma from two hemostatically normal individuals, genetically lacking the fifth component of complement (C5), failed to exhibit normal platelet aggregation, or serotonin release, in the presence of zymosan. This abnormality was found to reside in the C5D plasma rather than in...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 118; no. 1; pp. 12 - 16
Main Authors Breckenridge, R. T., Rosenfeld, S. I., Graff, K. S., Leddy, J. P.
Format Journal Article
LanguageEnglish
Published 01.01.1977
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Summary:Abstract Platelet-rich-plasma from two hemostatically normal individuals, genetically lacking the fifth component of complement (C5), failed to exhibit normal platelet aggregation, or serotonin release, in the presence of zymosan. This abnormality was found to reside in the C5D plasma rather than in the platelets as demonstrated by the inability of the deficient plasma to activate zymosan for the aggregation of washed normal platelets. The defect could be corrected by the addition of normal plasma, normal serum, or highly purified human C5. A plasma abnormality similar to that found in the C5D individuals was also noted in plasmas deficient in C3, C6, and C7; whereas C8 plasma D behaved normally. These data suggest that this platelet reaction requires late acting C components, perhaps as the complex, bound to the zymosan particles.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.118.1.12