The Determination of Chromium and Cobalt in Synovial Fluid by Inductively Coupled Plasma Mass Spectrometry

While periprosthetic tissue reactions to metallic debris from these prosthetic devices is well described in the medical literature, in this study we wanted to measure chromium and cobalt in the surrounding synovial fluid in patients with failed hip replacements and correlate it to venous blood and s...

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Bibliographic Details
Published inAmerican journal of clinical pathology Vol. 144; no. suppl_2; p. A054
Main Authors Day, Patrick, Eckdahl, Steven, Jannetto, Paul
Format Journal Article
LanguageEnglish
Published Oxford, UK Oxford University Press 01.10.2015
Subjects
Chromium
Cobalt
Joint surgery
Mass spectrometry
Mass spectroscopy
Plasma
Prostheses
Quality control
Scientific imaging
Synovial fluid
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Summary:While periprosthetic tissue reactions to metallic debris from these prosthetic devices is well described in the medical literature, in this study we wanted to measure chromium and cobalt in the surrounding synovial fluid in patients with failed hip replacements and correlate it to venous blood and serum levels of these ions. [...]the laboratory developed an inductively coupled plasma mass spectrometry method to quantify chromium and cobalt concentrations in human synovial fluid. [...]an accurate and precise inductively coupled plasma mass spectrometry method for the analysis of chromium and cobalt in human synovial fluid was developed and can now be used to further study the periprosthetic tissue reactions in metal-on-metal hip arthroplasty. © American Society for Clinical Pathology Am J Clin Pathol 2015;144:
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/144.suppl2.054