Adaptogenic and neuroprotective effects of lithium ascorbate

• Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 116; no. 12; p. 86
• Main Authors: Pronin, A V, Gromova, O A, Sardaryan, I S, Torshin, I Yu, Stel'mashuk, E V, Ostrenko, K S, Aleksandrova, O P, Genrikhs, E E, Khaspekov, L G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2016
• Subjects: Adaptation, Physiological - drug effects; Animals; Ascorbic Acid - pharmacology; Ascorbic Acid - therapeutic use; Cells, Cultured; Disease Models, Animal; Glutamic Acid - pharmacology; Lithium Compounds - pharmacology; Lithium Compounds - therapeutic use; Neurons - drug effects; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Rats; Rats, Wistar; Stress, Psychological - drug therapy
• ISSN: 1997-7298
• DOI: 10.17116/jnevro201611612186-91

Investigation of the neuroprotective properties of lithium ascorbate on the stress models in vivo and in vitro. Neurocytological and behavioral studies on nerve cell culture and animal stress models. Significant neuroprotective effect of lithium ascorbate in neuronal cultures exposed to glutamate toxicity and adaptogenic effect of this drug in stress model in rats were shown. The results suggest lithium ascorbate has a high neuroprotective potential in stress models in vivo and in vitro.