Effect of (8)-gingerol in guinea-pig ileal and tracheal smooth muscle preparations
(8)-Gingerol, a component of ginger, produced a long-lasting contractile response at concentration of 10^-5 M in isolated ileum and trachea from guinea-pig. Contractile response was absolutely dependent on the presence of extracellular Ca^2+ , and was resistant to tetrodotoxin and indomethacin. In i...
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Published in | Japanese Journal of Pharmacology Vol. 61; no. suppl.2; p. 291 |
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Main Authors | , , , |
Format | Journal Article |
Language | Japanese English |
Published |
The Japanese Pharmacological Society
1993
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Online Access | Get full text |
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Summary: | (8)-Gingerol, a component of ginger, produced a long-lasting contractile response at concentration of 10^-5 M in isolated ileum and trachea from guinea-pig. Contractile response was absolutely dependent on the presence of extracellular Ca^2+ , and was resistant to tetrodotoxin and indomethacin. In ileal longitudinal smooth muscle preparation, (8)-gingerol-induced contraction was completely inhibited in the presence of verapamil or valinomycin. In tracheal preparation, (8)-gingerol-induced contraction was markedly attenuated in the presence of verapamil or valinomycin, and was completely inhibited by supplementation with amiloride. These results suggest that (8)-gingerol mainly acted on Ca^2+ channels of isolated guinea-pig ileal and tracheal smooth muscle membranes. The action may be closely associated with the Ca^2+ influx through voltage-dependent Ca^2+ channels caused by depolarization of smooth muscle membrane. |
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ISSN: | 0021-5198 1347-3506 |
DOI: | 10.1016/S0021-5198(19)37590-0 |