Surgical management of pediatric intracranial CCM: a 10-year single center experience

• Published in: Journal of neurosurgical sciences
• Main Authors: Calloni, Tommaso, Carai, Andrea, Lioi, Francesco, Cavaliere, Marilou, DE Benedictis, Alessandro, Rossi, Sabrina, Randi, Franco, Rossi Espagnet, Maria C, Trivisano, Marina, Cesario, Claudia, Pisaneschi, Elisa, Marasi, Alessandra, Savioli, Alessandra, Giussani, Carlo G, Marras, Carlo E
• Format: Journal Article
• Language: English
• Published: Italy 13.04.2022
• ISSN: 1827-1855
• DOI: 10.23736/S0390-5616.22.05574-6

Cerebral cavernous malformations (CCMs) are low-flow vascular malformations made up of dilated vascular spaces without intervening parenchyma that can occur throughout the central nervous system. CCMs can occur sporadically or in familial forms. Presentation is diverse, ranging from asymptomatic discoveries to drug-resistant epilepsy and hemorrhages. We describe the surgical management of CCMs in pediatric patients at Bambino Gesù Children's Hospital in Rome over the last 10 years. The cases have been stratified based on the clinical presentation and the relevant literature is discussed accordingly. We discuss the rationale and technique used in these cases based on their presentation, as well as the generally positive outcomes we achieved with early surgical management, use of intra-operative ultrasound (ioUS) and intraoperative neuromonitoring. Surgical management of pediatric CCMs is a safe and effective strategy, low rates of postoperative morbidity and partial resection were observed.