Concanavalin A receptors in normal and inflamed oesophageal epithelium. A light and electron microscopic study

We have examined normal and inflamed oesophageal biopsies for the distribution of alpha-D-mannosyl and alpha-D-glucosyl residues using the concanavalin A--horse radish peroxidase--Diamino-benzidine (DAB) technique at the light and electron microscope level. Receptors were found on the epithelial sur...

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Bibliographic Details
Published inHistochemistry (Berlin) Vol. 57; no. 3; p. 255
Main Authors Hopwood, D, Logan, K R, Milne, G, Bouchier, I A
Format Journal Article
LanguageEnglish
Published Germany 15.09.1978
Subjects
Biopsy
Cell Membrane - analysis
Endoplasmic Reticulum - analysis
Epithelium - analysis
Esophagitis - metabolism
Esophagitis - pathology
Esophagus - analysis
Histocytochemistry
Humans
Lymphocytes - analysis
Neutrophils - analysis
Nuclear Envelope - analysis
Receptors, Concanavalin A - isolation & purification
Receptors, Drug - isolation & purification
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Summary:We have examined normal and inflamed oesophageal biopsies for the distribution of alpha-D-mannosyl and alpha-D-glucosyl residues using the concanavalin A--horse radish peroxidase--Diamino-benzidine (DAB) technique at the light and electron microscope level. Receptors were found on the epithelial surface and in the nuclear membrane and endoplasmic reticulum. A similar distribution was found with the intrusive lymphocytes and polymorphonuclear leucocytes in the inflamed state. Some of the increased intercellular debris from inflamed biopsies contained concanavalin A receptors.
ISSN:0301-5564
DOI:10.1007/BF00492085