EXPERIMENTAL STUDIES ON RENAL FUNCTION IN REPEATED HEMORRHAGIC HYPOTENSION
The author made experimental studies on 46 mongrel dogs to investigate the influence of servere hemorrhagic hypotension and repeated blood transfusion upon the renal function by means of the blood reservoir technique in which the blood pressure of so-called shock level of 80mmHg was maintained for a...
Saved in:
| Published in | Journal of the Japan Society of Blood Transfusion Vol. 7; no. 6; pp. 374 - 393 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Transfusion Medicine and Cell Therapy
1961
|
| Online Access | Get full text |
| ISSN | 0546-1448 1883-8383 |
| DOI | 10.3925/jjtc1958.7.374 |
Cover
| Abstract | The author made experimental studies on 46 mongrel dogs to investigate the influence of servere hemorrhagic hypotension and repeated blood transfusion upon the renal function by means of the blood reservoir technique in which the blood pressure of so-called shock level of 80mmHg was maintained for a certain period of time by massive hemorrhage and total shed blood was returned to the subject afterward. In the study he considered the individual difference of the experimental animal which was menifest in the divisions of the blood loss curve and he pursued the effect of administration of norepinephrine, ACTH, hydrocortisone and chlorpromazine upon the renal function, while he compared the difference between continuous and intermittent hemorrhagic hypotensions. 1. There is a definite decrease of the renal function by repeated hemorrhagic hypotension. There is, however, individual difference in the compensatory power against blood loss, and the disturbance of the renal function is not necessaaily proportional to the number of repetition of hemorrhage and transfusion. 2. The renal function clearly reveals the individual difference of compensatory power against hemorrhage which is disclosed in the division of the blood loss curve, and so it is possible to estimate the effect of equivalent transfusion given after sustained hemorrhagic hypotension by following up the renal function. 3. The effect of epinephrine and hydrocortisone upon the repeated hemorrhagic hypotension differs with the time of administration, and when given prior to the stage of marked reduction of renal clearance and oliguria they show a prominent effect in maintaining and improving the renal function. Chlorpromazine blocks the influence of repeated hemorrhagic hypotension and makes the effect of transfusion favorable without fail, while ACTH has no effect upon the renal function. 4. The change of the blood loss curve caused by drug administration is well comparable to that of renal function after blood transfusion. 5. The aftermath of massive hemorrhage upon the subject persists for a considerably long time even afrer transfusion, and repetition of massive hemorrhage and transfusion compromises the circulatory system and accerelates the progress of impairment of the renal function. |
|---|---|
| AbstractList | The author made experimental studies on 46 mongrel dogs to investigate the influence of servere hemorrhagic hypotension and repeated blood transfusion upon the renal function by means of the blood reservoir technique in which the blood pressure of so-called shock level of 80mmHg was maintained for a certain period of time by massive hemorrhage and total shed blood was returned to the subject afterward. In the study he considered the individual difference of the experimental animal which was menifest in the divisions of the blood loss curve and he pursued the effect of administration of norepinephrine, ACTH, hydrocortisone and chlorpromazine upon the renal function, while he compared the difference between continuous and intermittent hemorrhagic hypotensions. 1. There is a definite decrease of the renal function by repeated hemorrhagic hypotension. There is, however, individual difference in the compensatory power against blood loss, and the disturbance of the renal function is not necessaaily proportional to the number of repetition of hemorrhage and transfusion. 2. The renal function clearly reveals the individual difference of compensatory power against hemorrhage which is disclosed in the division of the blood loss curve, and so it is possible to estimate the effect of equivalent transfusion given after sustained hemorrhagic hypotension by following up the renal function. 3. The effect of epinephrine and hydrocortisone upon the repeated hemorrhagic hypotension differs with the time of administration, and when given prior to the stage of marked reduction of renal clearance and oliguria they show a prominent effect in maintaining and improving the renal function. Chlorpromazine blocks the influence of repeated hemorrhagic hypotension and makes the effect of transfusion favorable without fail, while ACTH has no effect upon the renal function. 4. The change of the blood loss curve caused by drug administration is well comparable to that of renal function after blood transfusion. 5. The aftermath of massive hemorrhage upon the subject persists for a considerably long time even afrer transfusion, and repetition of massive hemorrhage and transfusion compromises the circulatory system and accerelates the progress of impairment of the renal function. |
| Author | HATANO, Toshio |
| Author_xml | – sequence: 1 fullname: HATANO, Toshio organization: Department of Surgery School of Medicine, Keio University |
| BookMark | eNpNkE9PwkAQxTcGExG5eu4XaN3t_u2xwmJroCWlJHraLMugECym5eK3dxElHiaTefN7k8m7Rb3m0ABC9wRHNIn5w253dCThKpIRlewK9YlSNFRU0R7qY85ESBhTN2jYddsV5pQmWMWij571y1xX-UwXdToNFvVynOtFUBZBpQsvTJbFqM79mJ-UuU5rPQ4yPSurKkuf8lGQvc7LWhcLz9yh643ddzD87QO0nOh6lIXT0pPpNHSE8yb07xLBgEKcAIs5J3i9ElYwKSlOqHRCAXEMCAhwci2xBMVtIghb801sVzEdoOh817WHrmthYz7b7YdtvwzB5hSG-QvDSOPD8IbHs2HXHe0bXHDbHrduD_9x8VPedFm6d9saaOg3vbFlVw |
| ContentType | Journal Article |
| Copyright | The Japan Society of Transfusion Medicine and Cell Therapy |
| Copyright_xml | – notice: The Japan Society of Transfusion Medicine and Cell Therapy |
| DBID | AAYXX CITATION |
| DOI | 10.3925/jjtc1958.7.374 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1883-8383 |
| EndPage | 393 |
| ExternalDocumentID | 10_3925_jjtc1958_7_374 article_jjtc1958_7_6_7_6_374_article_char_en |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSF KQ8 MOJWN RJT AAYXX CITATION |
| ID | FETCH-LOGICAL-c155n-392164e3e29e425510db6a647730937c68e1c4e1e6ec7d707e85a9614d5f2ab23 |
| ISSN | 0546-1448 |
| IngestDate | Tue Jul 01 03:44:05 EDT 2025 Wed Sep 03 06:14:55 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 6 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c155n-392164e3e29e425510db6a647730937c68e1c4e1e6ec7d707e85a9614d5f2ab23 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjtc1958/7/6/7_6_374/_article/-char/en |
| PageCount | 20 |
| ParticipantIDs | crossref_primary_10_3925_jjtc1958_7_374 jstage_primary_article_jjtc1958_7_6_7_6_374_article_char_en |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | 1961 1961-00-00 |
| PublicationDateYYYYMMDD | 1961-01-01 |
| PublicationDate_xml | – year: 1961 text: 1961 |
| PublicationDecade | 1960 |
| PublicationTitle | Journal of the Japan Society of Blood Transfusion |
| PublicationTitleAlternate | J. j. t. m |
| PublicationYear | 1961 |
| Publisher | The Japan Society of Transfusion Medicine and Cell Therapy |
| Publisher_xml | – name: The Japan Society of Transfusion Medicine and Cell Therapy |
| References | 19) 津田: 薬学研究, 20: 71, 1948. 14) Laborit, H.: Réaction organique à I'Agression et Choc. 山口他訳最新医学社, 1956. 24) Trueta, J. et al.: Studies of Renal Circulation, charles C. Thomas, Springfield, Illinois, 1946. 31) Silverstein, M. E.: Surgical clin. North Am., 35: 319, 1955. 15) Lamson, P. D. & De Turk, W. E.: J. Pharmacol. & Exper. Therap., 83: 250, 1945. 49) Fritz, I. & Levine, R.: Am. J. Phisiol., 165: 456, 1951. 22) 渋沢: 最新医学, 11: 3047, 1956. 13) Arimoto, F. et al.: Am. J. Phisiol., 143: 198, 1945. 36) Perla, G. A. et al.: Proc. Soc. Exper. Biol. & Med., 43: 397, 1940. 51) Remington, J. W. et al.: Proc. Soc. Exper. Biol. & Med., 69: 150, 1948. 30) Howland, W. S. et al.: Geriatrics, 12: 147, 1957. 44) Garrod, O. et al.: J. Clin. Invest., 34: 761, 1955. 12) 岩瀬: 日輸会誌, 6: 185, 1959. 47) Soffer, L. J.: Diseases of the Endocrine Glands, Lea & Febiger, Philadelphia, 1956. 8) Phillips, R. A. et al.: Am. J. Phisiol., 145: 314, 1946. 23) Selkurt, E. E.: Am. J. Phisiol., 145: 376, 1945. 43) Boss, W. R. et al.: J. Clin. Endocrinol., 9: 658, 1949. 26) Page, I. H. & McCubbin, J. W.: Am. J. Phisiol., 173: 411, 1953. 39) Ingle, D. W.: Am. J. Phisiol., 139: 460, 1943. 3) Wiggers, C. J.: Physiology of Shock, Common wealth Fund., N. Y., 1950. 7) Corcoran, A. C. & Page, I. H.: J. Exper. Med., 78: 205, 1943. 45) Luetscher, J. A.: Medical Uses of Cortisone, the Blakiston Company, N. Y., 1954. 52) Glasser, O. & Page, I. H.: Am. J. Physiol., 154: 297, 1948. 37) Melby, J. C. et al.: Lancet, 1: 441, 1959. 20) Smith, H. W.: The Kideney. Structure and Function in Health and Disease, Oxford Univ. Press, N. Y. 1951. 29) Howland, W. S. et al.: J. A. M. A., 160: 1271, 1956. 41) Friedman, S. M. et al.: Endocrinol., 43: 123, 1948. 16) Delorme, E. J.: Lancet, 260: 259, 1951. 1) Guyton, A. C. et al.: Am. J. Physiol., 163: 529, 1950. 50) Wigers, C. J. et al.: Am. J. Phisiol., 153: 511, 1948. 48) Ramey, E. R. et al.: Am. J. Phisiol., 165: 450, 1951. 40) Frank, H. A.: Am. J. Phisiol., 180: 282, 1955 6) Rein, H. & Roessler, R.: Z. Biol., 89: 237, 1930. 27) Frank, E. D. et al.: Am. J. Phisiol., 186: 74, 1956. 46) Raisz, L. G. et al.: J. Clin. Invest., 36: 767, 1957. 33) Selye, H. et al.: Cand. Med. Assn. J., 43: 1, 1940. 35) Weil, P. G. et al.: Canad. Med. Assn. J., 43: 8, 1940. 10) 阿部: 血液と輸血, 3: 171, 1957. 55) 渋沢: 外科研究の進歩, 1: 57, 1957. 2) 遠山: 日外会誌, 56: 1496, 1955. 21) 渋沢: ショックの臨床, 医学書院, 1956. 25) Haddy, F. J. et al.: Circulation Research, 5: 247, 1957. 4) 上原: 日外会誌, 12: 2030, 1957. 38) Swingl, W. W. et al.: Am. J. Phisiol., 139: 481, 1943. 53) 林: 日外会誌, 56: 1221, 1956. 17) Overbey, D. T. et al.: Fed. Proc., 6: 173, 1947. 18) Smith, H. W.: Principles of Renal physiology, oxford Univ. Press, N. Y. 1956. 9) Selkurt, E. E.: Am. J. Phisiol., 145: 699, 1946. 42) Talbott, J. H. et al.: J. Clin. Invest., 21: 107, 1942. 5) Fine, J.: New Eng. J. M., 251: 889, 1954. 32) Kanse, B. S. & Miörner G.: Lancet, 1: 1121, 1959. 28) Moris, G. C.: Surgical Forum, V: 798, 1954. 34) Noble, R. L. & Collip, J. B.: J. Exper. Phisiol., 31: 201, 1942. 54) 川瀬: 日外会誌, 57: 109, 1956. 11) 阿部: 日外会誌, 掲載予定. |
| References_xml | – reference: 25) Haddy, F. J. et al.: Circulation Research, 5: 247, 1957. – reference: 4) 上原: 日外会誌, 12: 2030, 1957. – reference: 2) 遠山: 日外会誌, 56: 1496, 1955. – reference: 9) Selkurt, E. E.: Am. J. Phisiol., 145: 699, 1946. – reference: 19) 津田: 薬学研究, 20: 71, 1948. – reference: 29) Howland, W. S. et al.: J. A. M. A., 160: 1271, 1956. – reference: 49) Fritz, I. & Levine, R.: Am. J. Phisiol., 165: 456, 1951. – reference: 30) Howland, W. S. et al.: Geriatrics, 12: 147, 1957. – reference: 10) 阿部: 血液と輸血, 3: 171, 1957. – reference: 31) Silverstein, M. E.: Surgical clin. North Am., 35: 319, 1955. – reference: 21) 渋沢: ショックの臨床, 医学書院, 1956. – reference: 36) Perla, G. A. et al.: Proc. Soc. Exper. Biol. & Med., 43: 397, 1940. – reference: 45) Luetscher, J. A.: Medical Uses of Cortisone, the Blakiston Company, N. Y., 1954. – reference: 55) 渋沢: 外科研究の進歩, 1: 57, 1957. – reference: 27) Frank, E. D. et al.: Am. J. Phisiol., 186: 74, 1956. – reference: 40) Frank, H. A.: Am. J. Phisiol., 180: 282, 1955, – reference: 23) Selkurt, E. E.: Am. J. Phisiol., 145: 376, 1945. – reference: 53) 林: 日外会誌, 56: 1221, 1956. – reference: 20) Smith, H. W.: The Kideney. Structure and Function in Health and Disease, Oxford Univ. Press, N. Y. 1951. – reference: 38) Swingl, W. W. et al.: Am. J. Phisiol., 139: 481, 1943. – reference: 1) Guyton, A. C. et al.: Am. J. Physiol., 163: 529, 1950. – reference: 15) Lamson, P. D. & De Turk, W. E.: J. Pharmacol. & Exper. Therap., 83: 250, 1945. – reference: 18) Smith, H. W.: Principles of Renal physiology, oxford Univ. Press, N. Y. 1956. – reference: 7) Corcoran, A. C. & Page, I. H.: J. Exper. Med., 78: 205, 1943. – reference: 54) 川瀬: 日外会誌, 57: 109, 1956. – reference: 26) Page, I. H. & McCubbin, J. W.: Am. J. Phisiol., 173: 411, 1953. – reference: 37) Melby, J. C. et al.: Lancet, 1: 441, 1959. – reference: 17) Overbey, D. T. et al.: Fed. Proc., 6: 173, 1947. – reference: 33) Selye, H. et al.: Cand. Med. Assn. J., 43: 1, 1940. – reference: 44) Garrod, O. et al.: J. Clin. Invest., 34: 761, 1955. – reference: 22) 渋沢: 最新医学, 11: 3047, 1956. – reference: 5) Fine, J.: New Eng. J. M., 251: 889, 1954. – reference: 42) Talbott, J. H. et al.: J. Clin. Invest., 21: 107, 1942. – reference: 47) Soffer, L. J.: Diseases of the Endocrine Glands, Lea & Febiger, Philadelphia, 1956. – reference: 11) 阿部: 日外会誌, 掲載予定. – reference: 12) 岩瀬: 日輸会誌, 6: 185, 1959. – reference: 16) Delorme, E. J.: Lancet, 260: 259, 1951. – reference: 41) Friedman, S. M. et al.: Endocrinol., 43: 123, 1948. – reference: 48) Ramey, E. R. et al.: Am. J. Phisiol., 165: 450, 1951. – reference: 13) Arimoto, F. et al.: Am. J. Phisiol., 143: 198, 1945. – reference: 52) Glasser, O. & Page, I. H.: Am. J. Physiol., 154: 297, 1948. – reference: 51) Remington, J. W. et al.: Proc. Soc. Exper. Biol. & Med., 69: 150, 1948. – reference: 14) Laborit, H.: Réaction organique à I'Agression et Choc. 山口他訳最新医学社, 1956. – reference: 3) Wiggers, C. J.: Physiology of Shock, Common wealth Fund., N. Y., 1950. – reference: 35) Weil, P. G. et al.: Canad. Med. Assn. J., 43: 8, 1940. – reference: 39) Ingle, D. W.: Am. J. Phisiol., 139: 460, 1943. – reference: 6) Rein, H. & Roessler, R.: Z. Biol., 89: 237, 1930. – reference: 50) Wigers, C. J. et al.: Am. J. Phisiol., 153: 511, 1948. – reference: 43) Boss, W. R. et al.: J. Clin. Endocrinol., 9: 658, 1949. – reference: 8) Phillips, R. A. et al.: Am. J. Phisiol., 145: 314, 1946. – reference: 28) Moris, G. C.: Surgical Forum, V: 798, 1954. – reference: 24) Trueta, J. et al.: Studies of Renal Circulation, charles C. Thomas, Springfield, Illinois, 1946. – reference: 34) Noble, R. L. & Collip, J. B.: J. Exper. Phisiol., 31: 201, 1942. – reference: 32) Kanse, B. S. & Miörner G.: Lancet, 1: 1121, 1959. – reference: 46) Raisz, L. G. et al.: J. Clin. Invest., 36: 767, 1957. |
| SSID | ssib053390826 ssj0001818654 ssib005879765 ssib000872077 ssib058493955 |
| Score | 1.1608424 |
| Snippet | The author made experimental studies on 46 mongrel dogs to investigate the influence of servere hemorrhagic hypotension and repeated blood transfusion upon the... |
| SourceID | crossref jstage |
| SourceType | Index Database Publisher |
| StartPage | 374 |
| Title | EXPERIMENTAL STUDIES ON RENAL FUNCTION IN REPEATED HEMORRHAGIC HYPOTENSION |
| URI | https://www.jstage.jst.go.jp/article/jjtc1958/7/6/7_6_374/_article/-char/en |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Journal of the Japan Society of Blood Transfusion, 1961, Vol.7(6), pp.374-393 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLdgcOCCQIDY-FAOIA5RShOncSpOAbJlRUtKaaXuFNmOo7WVWsTSy_563rOTzJt2GBwaVY7tJH6_PP_svA9CPgyjofApr4C5KY5BtaknIszmTpkc8yoKlE4Gc5ZH2SKcLEfLa3Nb7V3SiIG8utOv5H-kCmUgV_SS_QfJ9p1CAfwH-cIRJAzHe8k4XU5hHYbh-DGmgeF2bpG7sxTteY4XubYQcU-xZJomoKTcLD0rZrMsOYHRz86nxTzNf3WbVC1HzVcXAInz_UY1l3v3hG82fOVeAcm-WLkf6XfX4rDIWicw3W57608o_Iq28CZqer2_tL7zZ8k8yQuNkB10trvecYAX1LdU0iiMPFiCGY2pjMqMY-rF1KSj6XQqs6Bj60dqUvK0Uy01yRFva3GgbBjwYr1uJIbCGbBB38wOl31rGuuNC2FZgz2UXfuSldD-IXkUMOaj1eePnzYDZcHQdsWNGRC0XsUBGcac8D1jA7o2puPWlVdv42FEQJ1rrx8bExoUb-HzzUe4QX0er4H9d5aDmszMn5GnrQSdxEDqOXmw5i_IxIaT08LJKXJHw8np4OScYomBk2PBybHg9JIsjtP5t8xrU214Egjl1oO7hXWzoioYK9DioKgrEXF0UsYv5UxGsfJlqHwVKckqNmQqHnGARliN6oCLgL4iB9vdVr0mTugLHglZB0LB6tv3MQChDCvBQlnVvJaH5FM3CuVvE1GlvFtkh-SLGaS-Xvum2fUi_YPa_Ul0VwTtcHTv67whTxDmZmPtLTlo_uzVO6CajXivwfIXoMxsng |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=EXPERIMENTAL+STUDIES+ON+RENAL+FUNCTION+IN+REPEATED+HEMORRHAGIC+HYPOTENSION&rft.jtitle=Nihon+Yuketsu+Gakkai+zasshi+%3D+Journal+of+the+Japan+Society+of+Blood+Transfusion&rft.au=HATANO%2C+Toshio&rft.date=1961&rft.issn=0546-1448&rft.eissn=1883-8383&rft.volume=7&rft.issue=6&rft.spage=374&rft.epage=393&rft_id=info:doi/10.3925%2Fjjtc1958.7.374&rft.externalDBID=n%2Fa&rft.externalDocID=10_3925_jjtc1958_7_374 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0546-1448&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0546-1448&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0546-1448&client=summon |