EXPERIMENTAL STUDIES ON RENAL FUNCTION IN REPEATED HEMORRHAGIC HYPOTENSION

• Published in: Journal of the Japan Society of Blood Transfusion Vol. 7; no. 6; pp. 374 - 393
• Main Author: HATANO, Toshio
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Transfusion Medicine and Cell Therapy 1961
• ISSN: 0546-1448; 1883-8383
• DOI: 10.3925/jjtc1958.7.374

The author made experimental studies on 46 mongrel dogs to investigate the influence of servere hemorrhagic hypotension and repeated blood transfusion upon the renal function by means of the blood reservoir technique in which the blood pressure of so-called shock level of 80mmHg was maintained for a certain period of time by massive hemorrhage and total shed blood was returned to the subject afterward. In the study he considered the individual difference of the experimental animal which was menifest in the divisions of the blood loss curve and he pursued the effect of administration of norepinephrine, ACTH, hydrocortisone and chlorpromazine upon the renal function, while he compared the difference between continuous and intermittent hemorrhagic hypotensions. 1. There is a definite decrease of the renal function by repeated hemorrhagic hypotension. There is, however, individual difference in the compensatory power against blood loss, and the disturbance of the renal function is not necessaaily proportional to the number of repetition of hemorrhage and transfusion. 2. The renal function clearly reveals the individual difference of compensatory power against hemorrhage which is disclosed in the division of the blood loss curve, and so it is possible to estimate the effect of equivalent transfusion given after sustained hemorrhagic hypotension by following up the renal function. 3. The effect of epinephrine and hydrocortisone upon the repeated hemorrhagic hypotension differs with the time of administration, and when given prior to the stage of marked reduction of renal clearance and oliguria they show a prominent effect in maintaining and improving the renal function. Chlorpromazine blocks the influence of repeated hemorrhagic hypotension and makes the effect of transfusion favorable without fail, while ACTH has no effect upon the renal function. 4. The change of the blood loss curve caused by drug administration is well comparable to that of renal function after blood transfusion. 5. The aftermath of massive hemorrhage upon the subject persists for a considerably long time even afrer transfusion, and repetition of massive hemorrhage and transfusion compromises the circulatory system and accerelates the progress of impairment of the renal function.