Dynamic Phenomena caused by a Shock Wave in the Brain: Real-Time Diagnoses of the Rat Exposed to a Laser-Induced Shock Wave

Recently, terrorism using explosive devices has been increasing, resulting in a large number of patients suffering from blastinduced traumatic brain injury (bTBI). However, the pathophysiology and mechanism of bTBI are not well understood and thus, methods for diagnosis and treatment of bTBI have no...

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Bibliographic Details
Published inNihon Rēzā Igakkai shi Vol. 35; no. 2; pp. 132 - 139
Main Authors Sato, Shunichi, Kawauchi, Satoko, Okuda, Wataru, Nishidate, Izumi, Nawashiro, Hiroshi
Format Journal Article
LanguageEnglish
Published Japan Society for Laser Surgery and Medicine 30.08.2014
Subjects
Blast-induced traumatic brain injury
laser-induced shock wave
long-lasting hypoxemia
rat model
real-time diagnosis
spreading depolarization
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Summary:Recently, terrorism using explosive devices has been increasing, resulting in a large number of patients suffering from blastinduced traumatic brain injury (bTBI). However, the pathophysiology and mechanism of bTBI are not well understood and thus, methods for diagnosis and treatment of bTBI have not yet been established. We applied a laser-induced shock wave (LISW) to the rat brain, for which various real-time diagnoses were performed. We observed spreading depolarization, longlasting vasoconstriction and hypoxemia-oligemia in the brain even under the LISW conditions causing no changes in systemic physiological parameters and limited hemorrhage and contusion in the cortex.
ISSN:0288-6200
1881-1639
DOI:10.2530/jslsm.jslsm-35_0019