Beyond Laryngoscopy: Current Objective Diagnostic Testing and Interpretation for LPR

Diagnosis of laryngopharyngeal reflux (LPR) has traditionally been based on clinical symptoms and laryngoscopy findings. More recent applications of dual pH multichannel intraluminal monitoring (dual pH-MII), high-resolution esophageal manometry (HRM), and salivary pepsin testing may allow for a mor...

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Bibliographic Details
Published inCurrent otorhinolaryngology reports Vol. 4; no. 1; pp. 43 - 48
Main Authors Little, R. E., Bock, J. M.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2016
Subjects
Laryngopharyngeal Reflux
Laryngopharyngeal Reflux (T. Carroll
Medicine
Medicine & Public Health
Otorhinolaryngology
Section Editor
Laryngopharyngeal reflux
Proton pump inhibitors
Pepsin
Esophageal pH monitoring
Impedance
Laryngoscopy
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Summary:Diagnosis of laryngopharyngeal reflux (LPR) has traditionally been based on clinical symptoms and laryngoscopy findings. More recent applications of dual pH multichannel intraluminal monitoring (dual pH-MII), high-resolution esophageal manometry (HRM), and salivary pepsin testing may allow for a more comprehensive assessment of patients with suspected LPR. The limitations of empiric proton pump inhibitor (PPI) trials to establish a diagnosis of laryngeal symptoms due to LPR are evolving, and objective diagnostic testing may be warranted in patients who fail to respond to PPI. Dual pH-MII, HRM, and salivary pepsin testing are currently under active study for improved diagnosis of reflux contributions to laryngeal symptoms. The clinical application of these diagnostic testing modalities has been validated in the literature, though more normative data in healthy controls and improved symptom association prediction algorithms are warranted.
ISSN:2167-583X
2167-583X
DOI:10.1007/s40136-016-0102-8