ChemInform Abstract: Umpolung Amide Synthesis Using Substoichiometric N-Iodosuccinimide (NIS) and Oxygen as a Terminal Oxidant

Reaction of α‐bromo‐nitroalkanes with amines using O2/NIS as oxidative catalytic system gives the respective amides with high stereoselectivity (dr <20:1).

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Bibliographic Details
Published inChemInform Vol. 46; no. 10; p. no
Main Authors Schwieter, Kenneth E., Shen, Bo, Shackleford, Jessica P., Leighty, Matthew W., Johnston, Jeffrey N.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.03.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
amide formation
carboxylic amides (acyclic compounds)
carboxylic amides (benzene compounds)
catalysis
catalysis, phase‐transfer catalysis
Oxygen
phase-transfer catalysis
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Summary:Reaction of α‐bromo‐nitroalkanes with amines using O2/NIS as oxidative catalytic system gives the respective amides with high stereoselectivity (dr <20:1).
Bibliography:ark:/67375/WNG-7P2Q32PT-7
ArticleID:CHIN201510056
istex:1364ECA075F024B1253CD20D3E972C9F47B6DA27
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201510056