The physiological insight of Coenzyme-Q10 administration in preventing the incidence of reperfusion arrhythmia among patients undergoing coronary artery bypass grafting surgery

• Published in: Journal of basic and clinical physiology and pharmacology Vol. 33; no. 6; pp. 695 - 701
• Main Authors: Louisa Fadjri Kusuma Wardhani, Ivana Purnama Dewi, Kresna Nugraha Setia Putra, Andrianto, Andrianto, Soemantri, Djoko
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter GmbH 01.11.2022
• Subjects: Cardiac arrhythmia; Coronary vessels; Heart surgery
• ISSN: 0792-6855; 2191-0286
• DOI: 10.1515/jbcpp-2021-0329

Reperfusion arrhythmia following cardiac surgery has long been studied as part of myocardial damage. Reperfusion injury is thought to be exacerbated by oxygen-free radicals, whereas arrhythmogenic oscillations in membrane potential are mediated by reactive oxygen. Coenzyme Q10 is a lipid-soluble antioxidant that inhibits lipid peroxidation in biological membranes and supplies ATP cell synthesis, required as the organism’s primary energy source. This process explains how Coenzyme Q10 helps stabilize membranes and avoids critical metabolite depletion that may relate to reperfusion arrhythmia. There is a reduction of iatrogenic Coenzyme Q10 after coronary artery bypass surgery (CABG). On the other hand, there is an increased inflammatory process and cellular demand post CABG procedure. It leads to ischemia that can be manifested as arrhythmia. Reperfusion arrhythmia was less common in patients who took Coenzyme Q10. These findings suggest that Coenzyme Q10 supplementation might help patients with heart surgery avoid reperfusion arrhythmia. However, a higher-quality randomized controlled study is needed to determine the effect of Coenzyme Q10 in preventing reperfusion arrhythmia in cardiac surgery patients.