Lost and Found in Translation Why Ribosomal Frameshifting Might Be the Next Antiviral Target

• Published in: Resonance Vol. 28; no. 9; pp. 1391 - 1400
• Main Author: Ayyub, Shreya Ahana
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 02.10.2023
• Subjects: Education; General Article; Humanities and Social Sciences; multidisciplinary; Science; Science Education; protein synthesis; SARS-CoV-2; antiviral therapeutics; Ribosome; HIV

Programmed ribosomal frameshifting (PRF) is a mechanism of recoding that allows the synthesis of multiple proteins from the same mRNA by shifting the translation reading frame. Many viruses, including the medically important HIV and coronaviruses, rely on PRF to increase their coding capacity and mo...