Lost and Found in Translation Why Ribosomal Frameshifting Might Be the Next Antiviral Target

Programmed ribosomal frameshifting (PRF) is a mechanism of recoding that allows the synthesis of multiple proteins from the same mRNA by shifting the translation reading frame. Many viruses, including the medically important HIV and coronaviruses, rely on PRF to increase their coding capacity and mo...

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Bibliographic Details
Published inResonance Vol. 28; no. 9; pp. 1391 - 1400
Main Author Ayyub, Shreya Ahana
Format Journal Article
LanguageEnglish
Published New Delhi Springer India 02.10.2023
Subjects
Education
General Article
Humanities and Social Sciences
multidisciplinary
Science
Science Education
protein synthesis
SARS-CoV-2
antiviral therapeutics
Ribosome
HIV
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Summary:Programmed ribosomal frameshifting (PRF) is a mechanism of recoding that allows the synthesis of multiple proteins from the same mRNA by shifting the translation reading frame. Many viruses, including the medically important HIV and coronaviruses, rely on PRF to increase their coding capacity and modulate appropriate stoichiometric ratios of viral proteins. Therefore, PRF is an attractive target for the development of antiviral therapeutics such as small molecule inhibitors, biomimetic peptides and attenuated viral vaccines.
ISSN:0973-712X
0973-712X
DOI:10.1007/s12045-023-1675-4