ChemInform Abstract: Iridium-Catalyzed Asymmetric Hydrogenation of 2-Pyridyl Cyclic Imines: A Highly Enantioselective Approach to Nicotine Derivatives

A substituent adjacent to the pyridine N atom is crucial to block the coordination ability of the pyridine moiety, an effect which is evidently overturned by the proximate second N atom in substrate (Vb).

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Bibliographic Details
Published inChemInform Vol. 46; no. 27; p. no
Main Authors Guo, Cui, Sun, Dong-Wei, Yang, Shuang, Mao, Shen-Jie, Xu, Xiao-Hua, Zhu, Shou-Fei, Zhou, Qi-Lin
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.07.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
catalysis
catalysis, phase‐transfer catalysis
diastereoselective syntheses
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)
enantioselective syntheses (incl. cis/trans-isomerism)
hydrogenation
phase-transfer catalysis
pyridine derivatives
pyrrole derivatives
reduction
reduction, hydrogenation
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Summary:A substituent adjacent to the pyridine N atom is crucial to block the coordination ability of the pyridine moiety, an effect which is evidently overturned by the proximate second N atom in substrate (Vb).
Bibliography:istex:DE0C03EFE850A92E13092D6D914A0B2C5EF3D5FD
ArticleID:CHIN201527143
ark:/67375/WNG-ML2G6RLX-T
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201527143