ChemInform Abstract: Organocatalytic Asymmetric Vinylogous Michael Addition of Dicyanoolefins to Imine Intermediates Generated in situ from Arenesulfonylalkylindoles

• Published in: ChemInform Vol. 44; no. 15; p. no
• Main Authors: Zhu, Xing-Li, He, Wu-Jun, Yu, Liang-Liang, Cai, Chang-Wu, Zuo, Zong-Le, Qin, Da-Bin, Liu, Quan-Zhong, Jing, Lin-Hai
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 09.04.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: C-C bond formation; diastereoselective syntheses; diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism); enantioselective syntheses (incl. cis/trans-isomerism); indole derivatives; indole derivatives, isoindole derivatives; isoindole derivatives; nitriles (benzene compounds); organocatalysis; pyrazole derivatives; thiopyran derivatives

The present first Michael addition provides an easy and convenient approach to C‐3 alkyl‐substituted indole derivatives with high enantioselectivities whereas diastereoselectivity depends on the cyano substrate.