ChemInform Abstract: Synthesis of Novel Spirooxindole Derivatives by One Pot Multicomponent Reaction and Their Antimicrobial Activity

1,3‐Dipolar cycloaddition of azomethine ylides, generated in situ via decarboxylative condensation of isatins (I) and (IX) and sarcosine (II) or (L)‐proline (X), to naphthoquinone (III), followed by spontaneous dehydrogenation afford the spirooxindoles (IV) and (XI), resp., in high yields.

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Bibliographic Details
Published inChemInform Vol. 43; no. 39; p. no
Main Authors Bhaskar, Gangaru, Arun, Yuvaraj, Balachandran, Chandrasekar, Saikumar, Chandrasekara, Perumal, Paramasivan T.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 25.09.2012
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
antibacterial activity
antibacterial activity, antimicrobial activity, antiprotozoal activity
antimicrobial activity
Antimicrobial agents
antiprotozoal activity
cycloaddition reactions
fused pyrrole derivatives
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Summary:1,3‐Dipolar cycloaddition of azomethine ylides, generated in situ via decarboxylative condensation of isatins (I) and (IX) and sarcosine (II) or (L)‐proline (X), to naphthoquinone (III), followed by spontaneous dehydrogenation afford the spirooxindoles (IV) and (XI), resp., in high yields.
Bibliography:ArticleID:CHIN201239130
istex:B844187EA0891F897A5DF648EA3438D1AFBEBDA1
ark:/67375/WNG-SHX22LRR-T
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201239130