Is It Possible to Prevent the Thanatogenetic Processes in Premature Babies?

• Published in: Clinics and practice Vol. 14; no. 5; pp. 1801 - 1817
• Main Authors: Ghitoi, Sinziana Andra, Deacu, Mariana, Aschie, Mariana, Enciu, Manuela, Mitroi, Anca Florentina, Cozaru, Georgeta Camelia, Nicolau, Antonela Anca, Orasanu, Cristian Ionut, Ursica, Oana Andreea, Voda, Raluca Ioana
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 02.09.2024
• Subjects: APGAR; preterm; stillborn; prevention
• ISSN: 2039-7275; 2039-7283; 2039-7283
• DOI: 10.3390/clinpract14050144

Preterm births comprise all pregnancies coming to an end before the gestational age of 37 weeks and remain the leading cause of death in children under 5 years old despite efforts to reduce their occurrence. We aim to analyze all morbidity and mortality data to understand causes and risk factors, helping in prevention efforts. This study includes 140 cases collected during 2018-2022. Demographic, maternal, and thanatogenetic data were statistically analyzed. We observed an upward slope of stillborn babies. In the case of live-born premature, the average survival was 301.76 h. The multivariate analysis noted that extremely low birth weight (HR = 5.141) and very low birth weight (HR = 4.177) are risk factors involved in mortality. Increased parity was associated with premature births with low and very low birth weight ( = 0.019). We observed that a mother's age of over 30 years is predictable for the development of pregnancy-induced hypertension. Cerebral and pulmonary hemorrhages were the most common intermediate morbid conditions, with prematurity and plurivisceral hemorrhages serving as their root causes. We have identified that anthropometric measurements have a high predictability on malformed babies. The identified associations indicate a shared mechanism for certain lesion processes, which can help optimize resources for predicting and preventing preterm neonatal issues.