Bradyrhizobium japonicum FixK 2 , a Crucial Distributor in the FixLJ-Dependent Regulatory Cascade for Control of Genes Inducible by Low Oxygen Levels

ABSTRACT Bradyrhizobium japonicum possesses a second fixK -like gene, fixK 2 , in addition to the previously identified fixK 1 gene. The expression of both genes depends in a hierarchical fashion on the low-oxygen-responsive two-component regulatory system FixLJ, whereby FixJ first activates fixK 2...

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Published inJournal of bacteriology Vol. 180; no. 19; pp. 5251 - 5255
Main Authors Nellen-Anthamatten, D., Rossi, P., Preisig, O., Kullik, I., Babst, M., Fischer, H. M., Hennecke, H.
Format Journal Article
LanguageEnglish
Published 01.10.1998
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Summary:ABSTRACT Bradyrhizobium japonicum possesses a second fixK -like gene, fixK 2 , in addition to the previously identified fixK 1 gene. The expression of both genes depends in a hierarchical fashion on the low-oxygen-responsive two-component regulatory system FixLJ, whereby FixJ first activates fixK 2 , whose product then activates fixK 1 . While the target genes for control by FixK 1 are unknown, there is evidence for activation of the fixNOQP , fixGHIS , and rpoN 1 genes and some heme biosynthesis and nitrate respiration genes by FixK 2 . FixK 2 also regulates its own structural gene, directly or indirectly, in a negative way.
ISSN:0021-9193
1098-5530
DOI:10.1128/JB.180.19.5251-5255.1998