Optimized isochronal late activation methods in the visualization and isthmus identification of ventricular tachycardia

• Published in: Heart rhythm
• Main Authors: Zeldin, Lawrence, Majumder, Jonah A., Yang, Haiqiu, Yarmohammadi, Hirad, Biviano, Angelo, Hennessey, Jessica, Wan, Elaine Y., Ciaccio, Edward J., Garan, Hasan, Hendon, Christine P., Saluja, Deepak
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.08.2024
• Subjects: Ablation; Isochronal late activation mapping; Isthmus; Velocity; Ventricular tachycardia; ROC; Ventricular tachycardia; IQR; Ablation; Velocity; ILAM; Isochronal late activation mapping; AUC; EAM; MAD; DZ; Isthmus; LAT; VT; Isochronal Late Activation Mapping; Ventricular Tachycardia
• ISSN: 1547-5271; 1556-3871; 1556-3871
• DOI: 10.1016/j.hrthm.2024.08.038

Catheter ablation of ventricular tachycardia (VT) during sinus rhythm often relies on isochronal late activation mapping (ILAM), a validated means of isthmus identification, whereby points are binned by local activation time (LAT) into 8 isochrones, and isthmus regions are identified as regions with isochronal crowding. The resulting output, however, is inherently discretized, and loss of LAT data occurs. To improve the precision of isthmus identification, we quantify isochronal density and assess the effect of increasing the number of isochrones used and the effectiveness of continuous metrics analogous to ILAM. The objective of this study was to determine whether current practices in ILAM calculation are optimized for isthmus detection. Patients undergoing VT ablation were included if high-density maps in both VT and sinus or paced rhythms were available. Isochronal density was assessed at differing numbers of isochrones, and isthmus discrimination was assessed. Continuous metrics that mimicked ILAM by assessing the local distribution of LAT values—using interquartile range or the median absolute deviation—were also defined and assessed. Eight electroanatomic maps (EAMs) were included. Isthmus discrimination improved progressively from a minimum area under the curve (AUC) of 0.600 when assessing the isochronal density of 8-isochrone EAMs to a maximum of 0.776 when assessing the density of 1000-isochrone EAMs (DeLong test, P < .0001). On logistic regression, the continuous metrics using interquartile range (AUC = 0.714) and median absolute deviation (AUC = 0.721) better discriminated isthmus identity than ILAM. Using more isochrones or using continuous ILAM analogues improves isthmus identification. By retaining more data, these metrics could increase the precision of VT ablation.